Cytomegalovirus and Schizophrenia
Cytomegalovirus and Schizophrenia
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巨细胞病毒和精神分裂症
DOI：
10.1192/bjp.146.5.503
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发表时间：
1985
影响因子：
10.5
通讯作者：
R. Dayton
中科院分区：
文献类型：
--
作者：
S. Shrikhande;S. Hirsch;J. Coleman;M. Reveley;R. Dayton
摘要 对 20 名长期住院的男性精神分裂症患者和 12 名急性精神分裂症患者的脑脊液 (CSF) 进行了抗巨细胞病毒抗体检查。使用灵敏且特异的酶免疫测定法检测精神分裂症患者和骨科患者脑脊液中的 IgG 或 I g M 类抗体，这些患者作为对照。在任一组的CSF中均未发现显着量的IgM抗体。在 32 名精神分裂症患者中，只有一名急性患者中发现了显着的 IgG 滴度，但在 4 名骨科患者中发现了显着的 IgG 滴度。结果不支持巨细胞病毒感染与精神分裂症之间的关联；如果出现这样的关联，那一定是不寻常的。
Summary Cerebrospinal fluid (CSF) from 20 chronically hospitalised male schizophrenics and from 12 patients admitted with acute schizophrenia were examined for antibodies against cytomegalovirus. A sensitive and specific enzyme-immunoassay was used to detect IgG or I g M classes of antibodies in the CSF of the schizophrenic patients and often orthopaedic patients, who served as controls. No significant amounts of I g M antibody were found in the CSF of either group. A significant titre of IgG was found in only one of the 32 schizophrenics, an acute patient, but in four of the orthopaedic patients. The results do not support an association of cytomegalovirus infection with schizophrenia; if such an association occurs, it must be unusual.