Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis
Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis
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DOI：
10.4049/jimmunol.164.9.4783
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发表时间：
2000-05-01
影响因子：
4.4
通讯作者：
Kolls, JK
中科院分区：
文献类型：
--
作者：
Schwarzenberger, P;Huang, WT;Kolls, JK
IL-17是一种新型的CD 4（+）T细胞限制性细胞因子。在体内，它刺激造血并引起由成熟粒细胞组成的嗜中性粒细胞。在这项研究中，我们表明，IL-17介导的粒细胞生成需要G-CSF的释放和存在或诱导的跨膜形式的干细胞因子（SCF）的最佳粒细胞生成。然而，IL-17还保护小鼠免受G-CSF中和诱导的中性粒细胞减少症，G-CSF中和完全逆转IL-17诱导的BM祖细胞扩增，而脾CFU-GM/CFU-粒细胞-红细胞-巨核细胞-单核细胞在Sl/Sld和同窝对照小鼠中仅减少50%。因此，IL-17对脾粒细胞生成仍有显著的SCF/G-CSF非依赖性作用，导致成熟循环粒细胞的保存。IL-17是一种细胞因子，可能将淋巴细胞和骨髓宿主防御相互联系，并可能具有治疗开发的潜力。
IL-17 is a novel, CD4(+) T cell-restricted cytokine. In vivo, it stimulates hematopoiesis and causes neutrophilia consisting of mature granulocytes. In this study, we show that IL-17-mediated granulopoiesis requires G-CSF release and the presence or induction of the transmembrane form of stem cell factor (SCF) for optimal granulopoiesis. However, IL-17 also protects mice from G-CSF neutralization-induced neutropenia, G-CSF neutralization completely reversed IL-17-induced BM progenitor expansion, whereas splenic CFU-GM/CFU-granulocyte-erythrocyte-megakaryocyte-monocyte was only reduced by 50% in both Sl/Sld and littermate control mice. Thus, there remained a significant SCF/G-CSF-independent effect of IL-17 on splenic granulopoiesis, resulting in a preservation of mature circulating granulocytes. IL-17 is a cytokine that potentially interconnects lymphocytic and myeloid host defense and may have potential for therapeutic development.