Functional dynamics of primate cortico-striatal networks during volitional movements.
Functional dynamics of primate cortico-striatal networks during volitional movements.
复制标题
自愿运动过程中灵长类皮质 - 纹状体网络的功能动力学。
DOI：
10.3389/fnsys.2014.00027
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发表时间：
2014
影响因子：
3
通讯作者：
Deadwyler S
中科院分区：
文献类型：
--
作者：
Santos L;Opris I;Hampson R;Godwin DW;Gerhardt G;Deadwyler S
运动皮质和背侧纹状体(尾状核和壳核)是运动加工的关键区域，但皮质和纹状体之间的界面尚不清楚。虽然背侧纹状体整合了来自多个大脑区域的信息来塑造运动学习和习惯形成，但皮质-纹状体回路的中断损害了这些回路的功能，导致了包括帕金森氏症在内的多种神经疾病。为了更好地了解皮质-纹状体回路的调制，我们同时记录了执行视觉运动任务的恒河猴四个脑区、初级运动皮质和感觉皮质的单个神经元活动，以及壳核的吻段和尾段。结果表明，两种药物(可卡因和巴氯芬)的单独给药改变了这些皮质-纹状体环路区域之间的空间和时间任务相关的放电关系。在正确的试验中，可卡因和巴氯芬严重扰乱了运动皮质和壳核神经元的空间调谐和相关放电，而这两种药物显著降低了运动皮质-纹状体网络的功能连接。这些发现提供了对与运动相关的皮质-纹状体放电的调节的洞察，并对帕金森氏病和相关疾病的治疗方法提供了启示。
The motor cortex and dorsal striatum (caudate nucleus and putamen) are key regions in motor processing but the interface between the cortex and striatum is not well understood. While dorsal striatum integrates information from multiple brain regions to shape motor learning and habit formation, the disruption of cortico-striatal circuits compromises the functionality of these circuits resulting in a multitude of neurologic disorders, including Parkinson's disease. To better understand the modulation of the cortico-striatal circuits we recorded simultaneously single neuron activity from four brain regions, primary motor, and sensory cortices, together with the rostral and caudal segments of the putamen in rhesus monkeys performing a visual motor task. Results show that spatial and temporal-task related firing relationships between these cortico-striatal circuit regions were modified by the independent administration of the two drugs (cocaine and baclofen). Spatial tuning and correlated firing of neurons from motor cortex and putamen were severely disrupted by cocaine and baclofen on correct trials, while the two drugs have dramatically decreased the functional connectivity of the motor cortical-striatal network. These findings provide insight into the modulation of cortical-striatal firing related to movement with implications for therapeutic approaches to Parkinson's disease and related disorders.