A convenient solution and solid-phase synthesis of Δ5-2-oxopiperazines via N-acyliminium ions cyclization
A convenient solution and solid-phase synthesis of Δ5-2-oxopiperazines via N-acyliminium ions cyclization
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DOI：
10.1016/s0040-4039(02)01403-x
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发表时间：
2002-09-02
影响因子：
1.8
通讯作者：
Nadzan, A
中科院分区：
文献类型：
--
作者：
Cheng, JF;Chen, M;Nadzan, A
通过 Ugi 四组分缩合反应 (U-4CC)，然后在醛（缩醛）官能团和新形成的酰胺键之间进行 N-酰亚胺离子环化，建立了在溶液相和固相载体上极其高效地合成 Delta(5)-2-氧代哌嗪的方法。以优异的收率和纯度获得了所需的 Delta(5)-2-氧代哌嗪。 (C) 2002 Elsevier Science Ltd. 保留所有权利。
An extremely efficient synthesis of Delta(5)-2-oxopiperazines in solution phase and on solid support has been established via a Ugi four-component condensation reaction (U-4CC) followed by N-acyliminium ion cyclization between the aldehyde (acetal) functionality and the newly formed amide bond. The desired Delta(5)-2-oxopiperazines are obtained in excellent yields and purity. (C) 2002 Elsevier Science Ltd. All rights reserved.