Saponins from the bark of Nephelium maingayi
Saponins from the bark of Nephelium maingayi
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DOI：
10.1021/np030389e
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发表时间：
2004-02-01
影响因子：
5.1
通讯作者：
Kinghorn, AD
中科院分区：
文献类型：
--
作者：
Ito, A;Chai, HB;Kinghorn, AD
对印度尼西亚采集的海参树皮进行活性导向分级分离，分离出6个新的皂苷(1-6)。其中4的苷元被鉴定为新化合物7α-甲氧基红二醇，1-3和5、6的苷元分别被鉴定为红二醇和甘露二醇(16β-羟基香兰素)。通过光谱数据解析确定了1-6的结构，并确定了酸解后其组成单糖的绝对构型为其噻唑烷衍生物。在分离的菌株中，只有化合物I和5对一组人类肿瘤细胞株显示出非常弱的细胞毒活性。
Activity-guided fractionation of the bark of Nephelium maingayi, collected in Indonesia, led to the isolation of six new saponins (1-6). The aglycon of 4 was determined to be a new compound, 7alpha-methoxyerythrodiol, and those of 1-3 and of 5 and 6 were identified as erythrodiol and maniladiol (16beta-hydroxyamyrin), respectively. The structures of 1-6 were determined on the basis of spectral data interpretation, and the absolute configurations of their component monosaccharides were determined as their thiazolidine derivatives after acid hydrolysis. Of the isolates, only compounds I and 5 showed very weak cytotoxic activity against a panel of human tumor cell lines.