A Heterologous MF59-Adjuvanted H5N1 Prepandemic Influenza Booster Vaccine Induces a Robust, Cross-Reactive Immune Response in Adults and the Elderly
A Heterologous MF59-Adjuvanted H5N1 Prepandemic Influenza Booster Vaccine Induces a Robust, Cross-Reactive Immune Response in Adults and the Elderly
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DOI：
10.1128/cvi.00461-09
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发表时间：
2010-11-01
影响因子：
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通讯作者：
Banzhoff, Angelika
中科院分区：
文献类型：
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作者：
Fragapane, Elena;Gasparini, Roberto;Banzhoff, Angelika
评价了在用异源毒株初次接种后约18个月给予的含有7.5 μ g A/turkey/Turkey/1/2005样（进化枝2.2）H5 N1血凝素的MF 59佐剂化H5 N1疫苗的加强剂量的免疫原性和安全性。加强疫苗耐受性良好，并诱导了强有力的交叉反应性免疫应答。
Immunogenicity and safety of a booster dose of an MF59-adjuvanted H5N1 vaccine containing 7.5 mu g A/turkey/Turkey/1/2005-like (clade 2.2) H5N1 hemagglutinin, given approximately 18 months after primary vaccination with a heterologous strain, were evaluated. The booster vaccine was well tolerated and induced a robust, cross-reactive immune response.