Obesity at the age of 50 y in men and women exposed to famine prenatally.
Obesity at the age of 50 y in men and women exposed to famine prenatally.
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DOI：
10.1093/ajcn/70.5.811
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发表时间：
1999-11
期刊：
影响因子：
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通讯作者：
A. Ravelli;J. Meulen;C. Osmond;D. Barker;O. Bleker
中科院分区：
文献类型：
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作者：
A. Ravelli;J. Meulen;C. Osmond;D. Barker;O. Bleker
背景它表明，在1944-1945年的荷兰饥荒期间怀孕的男性在19岁时肥胖率高于之前或之后怀孕的男性。目的我们的目的是研究产前暴露于荷兰饥荒对50岁时女性和男性肥胖的影响。我们测量了1943年11月至1947年2月在阿姆斯特丹出生的741人的身体尺寸。我们比较了在妊娠晚期、中期或早期暴露于饥荒的人（暴露参与者）和在饥荒期之前出生或之后怀孕的人（非暴露参与者）。结果：妊娠早期暴露于饥饿的50岁女性的体重指数（BMI;单位：kg/m2）显著高于对照组7。4%（95%CI：0.7%，14.5%）。在妊娠中期（-2.1%;-7.0%，3.1%）或妊娠晚期（-1.3%;-6.3%，3.9%）暴露的女性中，BMI无显著差异。在50岁的男性中，BMI在妊娠的任何阶段都不会受到饥饿的显著影响：BMI相差0.4%（-3.5%，4.5%）在妊娠晚期暴露于饥荒的男性中，妊娠中期暴露组与未暴露组相比，妊娠早期暴露组与未暴露组相比，血清中维生素C水平降低了0.5%（-4.6%，6.0%）。结论：妊娠早期母亲营养不良与50岁女性较高的BMI和腰围有关，但与男性无关。这些发现表明，在妊娠早期建立的中枢内分泌调节系统的扰动可能有助于在以后的生活腹型肥胖的发展。
BACKGROUND It was shown that men who were conceived during the Dutch famine of 1944-1945 had higher rates of obesity at age 19 y than those conceived before or after it. OBJECTIVE Our objective was to study the effects of prenatal exposure to the Dutch famine on obesity in women and men at age 50 y. DESIGN We measured the body size of 741 people born at term between November 1943 and February 1947 in Amsterdam. We compared people exposed to famine in late, mid, or early gestation (exposed participants) with those born before or conceived after the famine period (nonexposed participants). RESULTS The body mass index (BMI; in kg/m(2)) of 50-y-old women exposed to famine in early gestation was significantly higher by 7. 4% (95% CI: 0.7%, 14.5%) than that of nonexposed women. BMI did not differ significantly in women exposed in mid gestation (-2.1%; -7.0%, 3.1%) or in late gestation (-1.3%; -6.3%, 3.9%). In 50-y-old men, BMI was not significantly affected by exposure to famine during any stage of gestation: BMI differed by 0.4% (-3.5%, 4.5%) in men exposed to famine in late gestation, by -1.2% (-5.5%, 3.3%) in those exposed in mid gestation, and by 0.5% (-4.6%, 6.0%) in those exposed in early gestation compared with nonexposed men. CONCLUSIONS Maternal malnutrition during early gestation was associated with higher BMI and waist circumference in 50-y-old women but not in men. These findings suggest that pertubations of central endocrine regulatory systems established in early gestation may contribute to the development of abdominal obesity in later life.