Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung.
Anesthetics isoflurane and sevoflurane attenuate flagellin-mediated inflammation in the lung.
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DOI：
10.1016/j.bbrc.2021.04.045
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发表时间：
2021-06-11
影响因子：
3.1
通讯作者：
Koutsogiannaki S
中科院分区：
文献类型：
--
作者：
Yuki K;Mitsui Y;Shibamura-Fujiogi M;Hou L;Odegard KC;Soriano SG;Priebe GP;Koutsogiannaki S
异氟烷和七氟烷是临床上广泛使用的全身麻醉的挥发性麻醉药。我们和其他人以前已经表明，VA具有免疫调节作用，并可能对疾病状态的进展产生重大影响。鞭毛蛋白是革兰氏阴性菌的一种成分，通过与Toll样受体5（TLR 5）结合，在细菌性肺炎的病理生理学中发挥重要作用。我们的研究结果表明，VA，而不是静脉麻醉剂，显着衰减TLR 5的激活和中性粒细胞趋化因子IL-8从肺上皮细胞的释放。此外，鞭毛蛋白诱导的肺损伤显着衰减VA通过抑制中性粒细胞迁移到支气管肺泡腔。囊性纤维化（CF）患者的肺部高度定植铜绿假单胞菌，导致炎症。对接受VA与静脉麻醉的CF患者的氧合进行的回顾性研究表明，VA可能对气体交换具有保护作用。为了了解VA和TLR 5之间的相互作用，进行了对接模拟，这表明异氟烷和七氟烷对接到TLR 5和鞭毛蛋白之间的结合界面。
Isoflurane and sevoflurane are volatile anesthetics (VA) widely used in clinical practice to provide general anesthesia. We and others have previously shown that VAs have immunomodulatory effects and may have a significant impact on the progression of disease states. Flagellin is a component of Gram negative bacteria and plays a significant role in the pathophysiology of bacterial pneumonia through its binding to Toll-like Receptor 5 (TLR5). Our results showed that VAs, not an intravenous anesthetic, significantly attenuated the activation of TLR5 and the release of the neutrophil chemoattractant IL-8 from lung epithelial cells. Furthermore, flagellin-induced lung injury was significantly attenuated by VAs by inhibiting neutrophil migration to the bronchoalveolar space. The lungs of cystic fibrosis (CF) patients are highly colonized by Pseudomonas aeruginosa, which causes inflammation. The retrospective study of oxygenation in patients with CF who had received VA versus intravenous anesthesia suggested that VAs might have the protective effect for gas exchange. To understand the interaction between VAs and TLR5, a docking simulation was performed, which indicated that isoflurane and sevoflurane docked into the binding interphase between TLR5 and flagellin.
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影响因子：
4.4
作者：
Maaser, C;Heidemann, J;Kucharzik, T
通讯作者：
Kucharzik, T
影响因子：
3.8
作者：
Escobar, MA;Grosfeld, JL;Rescorla, FJ
通讯作者：
Rescorla, FJ
影响因子：
5.5
作者：
Tseng, J;Do, J;Machen, TE
通讯作者：
Machen, TE
影响因子：
4.8
作者：
Yuki, Koichi;Bu, Weiming;Eckenhoff, Roderic G.
通讯作者：
Eckenhoff, Roderic G.
DOI：
10.1186/1476-9255-2-16
发表时间：
2005-11-29
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Ritter M;Mennerich D;Weith A;Seither P
通讯作者：
Seither P