The development of a sleep apnea screening program in Romanian type 2 diabetic patients: a pilot study.
The development of a sleep apnea screening program in Romanian type 2 diabetic patients: a pilot study.
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罗马尼亚 2 型糖尿病患者睡眠呼吸暂停筛查计划的制定：一项试点研究。
DOI：
10.1007/s00592-010-0177-5
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发表时间：
2012
影响因子：
3.8
通讯作者：
Bala,Cornelia
中科院分区：
文献类型：
--
作者：
Rusu,Adriana;Todea,Doina;Rosca,Loredana;Nita,Cristina;Bala,Cornelia
确定在罗马尼亚2型糖尿病和肥胖患者中实施睡眠呼吸暂停筛查计划的可行性，这些患者在一家糖尿病中心的门诊就诊(罗马尼亚常规护理的标准)。对连续80名2型糖尿病患者进行了爱普沃斯嗜睡量表测试，体重指数≥为30 mg/m2。在这一标准下得分>；10的患者被要求进行多导睡眠监测以进行睡眠研究。总体而言，这些患者中有20%的人白天过度嗜睡(Epworth嗜睡量表>；10)，在所有这些病例中，阻塞性睡眠呼吸暂停都得到证实。在这些患者中，33.3%的患者有中度阻塞性睡眠呼吸暂停(AHI=15-30次/小时睡眠)，58.3%的患者有重度阻塞性睡眠呼吸暂停(AHI≥30次/小时睡眠)。与非呼吸暂停患者相比，阻塞性睡眠呼吸暂停患者男性更多，BMI更高，腰围更高，高密度脂蛋白-胆固醇更低。两组患者的糖化血红蛋白、糖尿病病程和年龄无统计学差异。腹围每增加1厘米，OSA优势增加1.1倍(95%CI：1.01~1.13)；BMI每增加1 kg/m2，OSA优势增加1.2倍(95%CI：1.05~1.38)。即使在调整了年龄和性别后，这些相关性在统计上仍然显著。调查人群中阻塞性睡眠呼吸暂停综合征的患病率较高。这些发现表明，需要更多关于罗马尼亚2型糖尿病患者阻塞性睡眠呼吸暂停发生率的数据。此外，发现的关联可能构成制定罗马尼亚2型糖尿病患者睡眠呼吸暂停筛查的具体建议的基础。
To determine the feasibility of a sleep apnea screening program in Romanian patients with type 2 diabetes and obesity attending outpatient clinic of a diabetes center (the standard for routine care in Romania). The Epworth Sleepiness Scale was administered to 80 consecutive patients with type 2 diabetes and a body mass index (BMI) ≥30 kg/m2. Patients with a score >10 at this scale were referred to polysomnography for a sleep study. Overall, 20% of these patients had excessive daytime sleepiness (Epworth Sleepiness Scale >10), and in all of these cases, obstructive sleep apnea was confirmed. Of these patients, 33.3% had moderate OSA (AHI = 15–30 events/h of sleep), and 58.3% had severe OSA (AHI ≥30 events/h of sleep). Individuals with OSA were more frequent males, have higher BMI, higher waist circumference, and lower HDL-cholesterol compared with non-apneic subjects. Hb A1c, diabetes duration, and age were not statistically different between the two groups. OSA odds increased 1.1 times with every 1-cm increase in abdominal circumference (95%CI: 1.01–1.13) and 1.2 times with every kg/m2 increase in BMI (95%CI: 1.05–1.38). These associations remained statistically significant even after adjustment for age and sex. The prevalence of OSA in the sampled population was high. These findings suggest the need for more data regarding prevalence of obstructive sleep apnea in Romanian patients with type 2 diabetes. Furthermore, associations found may form a basis to develop specific recommendations for screening of sleep apnea in patients with type 2 diabetes from Romania.