Anaphylactic Transfusion Reaction in a Patient with Anhaptoglobinemia: The First Case in Korea
Anaphylactic Transfusion Reaction in a Patient with Anhaptoglobinemia: The First Case in Korea
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DOI：
10.3343/alm.2012.32.4.304
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发表时间：
2012-07-01
影响因子：
4.9
通讯作者：
Kim, Hyun Ok
中科院分区：
文献类型：
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作者：
Kim, Hyunsoo;Choi, Jonghyeon;Kim, Hyun Ok
过敏性输血反应是输血的罕见并发症。在亚洲发病率很高的一种疾病-触珠蛋白血症，在严重的情况下可引起过敏性输血反应或速发过敏反应。一名50岁的韩国妇女被诊断为复发性急性早幼粒细胞白血病。她在化疗期间出现血小板减少症，并在开始输注血小板浓缩液后立即在第4次和第5次血小板输注时发生过敏性输血反应。血液分析显示未检测到血清结合珠蛋白。我们检查了她的遗传表型，并检测到anhaptoglobinemia，这是因为在Hp基因簇的等位基因缺失。通过进行ELISA检测针对触珠蛋白的抗体的存在。为防止过敏反应，在清洗后输注单采血小板。因此，未发生过敏性输血反应。在这里，我们报告的第一例缺触球蛋白血症引起过敏性输血反应在韩国。
Anaphylactic transfusion reactions are rare complications of blood transfusions. Anhaptoglobinemia, a condition that has high incidence in Asia, can cause allergic transfusion reactions or anaphylaxis in severe cases. A 50-yr-old Korean woman was diagnosed with relapsed acute promyelocytic leukemia. She developed thrombocytopenia during chemotherapy and an anaphylactic transfusion reaction on the 4th and 5th platelet transfusions immediately after the transfusion of the platelet concentrates was initiated. Blood analysis showed no detectable serum haptoglobin. We examined her genetic phenotype and detected anhaptoglobinemia, which occurs because of an allelic deletion in the Hp gene cluster. The presence of an antibody against haptoglobin was detected by performing ELISA. To prevent anaphylactic reactions, apheresis platelets were transfused after washing. Consequently, anaphylactic transfusion reactions did not develop. Here, we report the first case of anhaptoglobinemia causing anaphylactic transfusion reaction in Korea.