Heritability of DTI and MTR in nine-year-old children
Heritability of DTI and MTR in nine-year-old children
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DOI：
10.1016/j.neuroimage.2010.03.017
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发表时间：
2010-11-15
期刊：
影响因子：
5.7
通讯作者：
Pol, Hilleke E. Hulshoff
中科院分区：
文献类型：
--
作者：
Brouwer, Rachel M.;Mandl, Rene C. W.;Pol, Hilleke E. Hulshoff
大脑的总体尺寸在一生中具有显着的遗传性。基因对局灶性灰质和白质密度变化的影响不太明显，并且可能随年龄而变化。本文描述了基因和环境对白质微结构变化的相对影响，通过扩散张量成像和磁化转移成像沿纤维束测量了来自同卵双胞胎和异卵双胞胎的 185 名 9 岁儿童样本。分数各向异性是微观结构方向性的衡量标准，不受遗传因素的显着影响。相比之下，分别研究纵向和径向扩散率，我们发现胼胝体膝部和压部以及右上纵束的径向和纵向扩散率均具有显着的遗传效应。此外，影响磁化转移比（MTR）（假定代表髓鞘形成）的遗传因素在位于大脑后部的胼胝体压部和上纵束中最为明显。遗传和环境因素影响各种扩散参数和MTR的程度差异表明，不同的生理机制（遗传或环境）是九岁时这些特征的基础。 (c) 2010 Elsevier Inc. 保留所有权利。
Overall brain size is strikingly heritable throughout life. The influence of genes on variation in focal gray and white matter density is less pronounced and may vary with age. This paper describes the relative influences of genes and environment on variation in white matter microstructure, measured along fiber tracts with diffusion tensor imaging and magnetization transfer imaging, in a sample of 185 nine-year old children from monozygotic and dizygotic twin pairs. Fractional anisotropy, a measure of microstructural directionality, was not significantly influenced by genetic factors. In contrast, studying longitudinal and radial diffusivity separately, we found significant genetic effects for both radial and longitudinal diffusivity in the genu and splenium of the corpus callosum and the right superior longitudinal fasciculus. Moreover, genetic factors influencing the magnetization transfer ratio (MTR), putatively representing myelination, were most pronounced in the splenium of the corpus callosum and the superior longitudinal fasciculi, located posterior in the brain. The differences in the extent to which genetic and environmental factors influence the various diffusion parameters and MTR, suggest that different physiological mechanisms (either genetic or environmental) underlie these traits at nine years of age. (c) 2010 Elsevier Inc. All rights reserved.