Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria.
Malaria vaccine efficacy: the difficulty of detecting and diagnosing malaria.
复制标题
疟疾疫苗功效：检测和诊断疟疾的困难。
DOI：
10.1186/1475-2875-6-36
复制
发表时间：
2007-03-26
期刊：
影响因子：
3
通讯作者：
中科院分区：
文献类型：
--
作者：
新的资金来源重振了控制疟疾的努力。在抗击这种毁灭性疾病的斗争中，一种有效的疫苗将是一笔巨大的财富，正在投入越来越多的财政和科学资源来开发一种疫苗。一些候选药物已经在I期和II期临床试验中进行了测试，其他几个候选药物即将开始试验。一些研究很有希望，但另一些研究则令人失望。很难比较这些临床试验的结果；即使是同一疫苗的独立试验也会得出高度不同的结果。评估疟疾疫苗的一个主要障碍是诊断临床疟疾的难度。这项分析评估了诊断错误，特别是显微镜引入的诊断错误对疟疾疫苗疗效试验结果的影响，并为改进未来的试验提出了建议。
New sources of funding have revitalized efforts to control malaria. An effective vaccine would be a tremendous asset in the fight against this devastating disease and increasing financial and scientific resources are being invested to develop one. A few candidates have been tested in Phase I and II clinical trials, and several others are poised to begin trials soon. Some studies have been promising, and others disappointing. It is difficult to compare the results of these clinical trials; even independent trials of the same vaccine give highly discrepant results. One major obstacle in evaluating malaria vaccines is the difficulty of diagnosing clinical malaria. This analysis evaluates the impact of diagnostic error, particularly that introduced by microscopy, on the outcome of efficacy trials of malaria vaccines and make recommendations for improving future trials.