Estrogenicity of resin-based composites and sealants used in dentistry.
Estrogenicity of resin-based composites and sealants used in dentistry.
复制标题
DOI：
10.1289/ehp.96104298
复制
发表时间：
1996-03
影响因子：
10.4
通讯作者：
Sonnenschein C
中科院分区：
文献类型：
--
作者：
Olea N;Pulgar R;Pérez P;Olea-Serrano F;Rivas A;Novillo-Fertrell A;Pedraza V;Soto AM;Sonnenschein C
我们测试了一些用于牙科的树脂基复合材料的雌激素活性。基于双酚 A 二缩水甘油醚甲基丙烯酸酯 (bis-GMA) 的密封剂可增加人雌激素靶标、血清敏感的 MCF7 乳腺癌细胞的细胞产量、孕激素受体表达和 pS2 分泌。雌激素是由双酚 A 和双酚 A 二甲基丙烯酸酯引起的，这两种单体存在于牙科密封剂的基膏中，并通过质谱法进行了鉴定。在治疗前和治疗后 1 小时，收集了 18 名受试者的唾液样本，这些受试者接受了 50 毫克双 GMA 基封闭剂的涂敷于其臼齿上。仅在治疗后 1 小时内收集的唾液中检测到双酚-A（范围 90-931 微克）。基于双 GMA 的树脂在牙科中的使用，尤其是儿童密封剂的使用，似乎会导致人类接触异雌激素。
We tested some resin-based composites used in dentistry for their estrogenic activity. A sealant based on bisphenol-A diglycidylether methacrylate (bis-GMA) increased cell yields, progesterone receptor expression, and pS2 secretion in human estrogen-target, serum-sensitive MCF7 breast cancer cells. Estrogenicity was due to bisphenol-A and bisphenol-A dimethacrylate, monomers found in the base paste of the dental sealant and identified by mass spectrometry. Samples of saliva from 18 subjects treated with 50 mg of a bis-GMA-based sealant applied on their molars were collected 1 hr before and after treatment. Bisphenol-A (range 90-931 micrograms) was identified only in saliva collected during a 1-hr period after treatment. The use of bis-GMA-based resins in dentistry, and particularly the use of sealants in children, appears to contribute to human exposure to xenoestrogens.