An exceptional mutational event leading to Chanarin-Dorfman syndrome in a large consanguineous family
An exceptional mutational event leading to Chanarin-Dorfman syndrome in a large consanguineous family
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DOI：
10.1111/j.1365-2133.2011.10252.x
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发表时间：
2011-06-01
影响因子：
10.3
通讯作者：
Sprecher, E.
中科院分区：
文献类型：
--
作者：
Samuelov, L.;Fuchs-Telem, D.;Sprecher, E.
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P>BackgroundPersistent pigment darkening (PPD) is a widely used in vivo method for measurement of ultraviolet (UV) A protection factor (UVAPF). However, with increased emphasis on UVA protection and sunscreen products with higher UVAPF gaining popularity, the immediate pigment darkening (IPD) method is drawing attention again. Furthermore, only about a quarter of the recommended quantity of sunscreen is used during daily activities. However, there is as yet no clearly defined relationship between the UVAPF and the amount of sunscreen applied.ObjectivesTo analyse the differences between the IPD and PPD methods, and to establish a relationship between the quantity of sunscreen application and the UVAPF.MethodsDifferent doses of sunscreen were applied on the back of 15 healthy volunteers, and the UVAPF was measured using both the IPD and the PPD methods.ResultsBoth methods proved to be effective for measuring the UVAPF. However, all the UVAPF values determined by the PPD method were lower than those determined by the IPD method. Additionally, an exponential relationship between the amount of sunscreen applied and the UVAPF was observed.ConclusionsThe IPD method can also be used as an appropriate endpoint in the determination of UVA protection. It is time saving, and thus considerably lowers the risk of UV exposure, particularly when testing sunscreen products with higher UVAPF. We further state that in order to achieve the desired protective effect of the sunscreen, the quantity of application is also very important.