Patient characteristics, clinical course and factors associated to ICU mortality in critically ill patients infected with SARS-CoV-2 in Spain: A prospective, cohort, multicentre study
Patient characteristics, clinical course and factors associated to ICU mortality in critically ill patients infected with SARS-CoV-2 in Spain: A prospective, cohort, multicentre study
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DOI：
10.1016/j.redar.2020.07.003
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发表时间：
2020-10-01
影响因子：
1.3
通讯作者：
Hernandez-Sanz, M. L.
中科院分区：
文献类型：
--
作者：
Ferrando, C.;Mellado-Artigas, R.;Hernandez-Sanz, M. L.
背景资料：COVID-19重症患者在重症监护室（UCI）住院期间的临床病程，包括内科和感染性并发症和支持治疗，以及其与ICU死亡率的相关性尚未得到充分报道。目的：本研究旨在描述ICU COVID-19患者的临床特征和临床病程，并确定COVID-19患者ICU死亡率的风险因素。方法前瞻性、多中心、队列研究，纳入来自西班牙和安道尔的30个ICU的重症COVID-19患者。2020年3月12日至5月26日期间，如果患者在研究期间死亡或从ICU出院，则入选连续患者。统计学，症状，生命体征，实验室指标，支持治疗，药物治疗，内科和感染并发症的报告和比较死亡和出院patients.Results：共663例患者。总体ICU死亡率为31%（203例患者）。在ICU入院时，死亡者的血氧不足程度更高[SpO 2在无再呼吸器面罩下为90（IQR 83至93）vs. 91（IQR 87至94）; P
Background: The clinical course of COVID-19 critically ill patients, during their admission in the intensive care unit (UCI), including medical and infectious complications and support therapies, as well as their association with in-ICU mortality has not been fully reported.Objective: This study aimed to describe clinical characteristics and clinical course of ICU COVID-19 patients, and to determine risk factors for ICU mortality of COVID-19 patients. Methods Prospective, multicentre, cohort study that enrolled critically ill COVID-19 patients admitted into 30 ICUs from Spain and Andorra. Consecutive patients from March 12th to May 26th, 2020 were enrolled if they had died or were discharged from ICU during the study period. Demographics, symptoms, vital signs, laboratory markers, supportive therapies, pharmacological treatments, medical and infectious complications were reported and compared between deceased and discharged patients.Results: A total of 663 patients were included. Overall ICU mortality was 31% (203 patients). At ICU admission non-survivors were more hypoxemic [SpO2 with non-rebreather mask, 90 (IQR 83 to 93) vs. 91 (IQR 87 to 94); P