Ultrahigh resolution optical coherence tomography in macular dystrophy
Ultrahigh resolution optical coherence tomography in macular dystrophy
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DOI：
10.1016/j.ajo.2005.06.029
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发表时间：
2005-12-01
影响因子：
4.2
通讯作者：
Drexler, W
中科院分区：
文献类型：
--
作者：
Wirtitsch, MG;Ergun, E;Drexler, W
目得：目的：用高分辨率光学相干断层扫描（UHR OCT）观察和研究黄斑营养不良的视网膜内改变。设计：前瞻性观察病例系列。方法：地点：奥地利维也纳医科大学基督教多普勒实验室眼科和生物医学工程与物理中心。病人：13例（23只眼）成人发作的黄斑中心凹卵黄状营养不良（AOFVD）和14例（27只眼）与Stargardt病（SD）或眼底黄斑（FF）。观察：成像使用一个紧凑的，新一代的UHR OCT系统，实现了显着改善可视化的视网膜内层，特别是感光层。主要观察指标：UHR OCT断层图像将AOFVD和SD/FF形态学的视网膜内差异可视化为沉积物的位置和延伸以及光感受器的损失。中央凹厚度定义为内界膜与感光细胞/视网膜色素上皮界面之间的距离。结果：AOFVD患者的感光细胞层基本完整，中央凹厚度为142 +/- 23 μ m，以及视网膜下沉积物。SD患者通常具有弥漫性退行性改变，所有视网膜内层的厚度可见减少，导致中央凹厚度（94 +/- 38 μ m）相应减少和光感受器（PR）的中央损失。AOFVD组与SD/FF组的中心凹厚度比较差异有统计学意义（P
PURPOSE: To visualize and investigate intraretinal changes in macular dystrophies with ultrahigh resolution optical coherence tomography (UHR OCT).DESIGN: Prospective observational case series.METHODS: SETTING: Department of Ophthalmology and Center for Biomedical Engineering and Physics, Christian Doppler Laboratory, Medical University of Vienna, Vienna, Austria. PATIENTS: Thirteen patients (23 eyes) with adult-onset foveomacular vitelliform dystrophy (AOFVD) and 14 patients (27 eyes) with Stargardt's disease (SD) or fundus flavimaculatus (FF).OBSERVATIONS: Imaging using a compact, new generation UHR OCT system, achieving considerably improved visualization of intraretinal layers, especially the photoreceptor layer. MAIN OUTCOME MEASURES: UHR OCT tomograms visualizing intraretinal differences in morphology of AOFVD and SD/FF as location and extension of deposits and loss of photoreceptors. Central foveal thickness defined as distance between internal limiting membrane and photoreceptors/retinal pigment epithelium interface.RESULTS: Patients with AOFVD had a mostly intact photoreceptor layer, a central foveal thickness of 142 +/- 23 mu m as well as subretinal deposits. Patients with SD generally had a diffuse degenerative change with a visible reduction in thickness of all intraretinal layers, resulting in a corresponding reduction of central foveal thickness (94 +/- 38 mu m) and central loss of photoreceptors (PRs). Comparative central foveal thickness of patients with AOFVD and SD/FF was significantly different (P