DOSE-RESPONSE ANALYSIS OF INFANTS PRENATALLY EXPOSED TO METHYL MERCURY - AN APPLICATION OF A SINGLE COMPARTMENT MODEL TO SINGLE-STRAND HAIR ANALYSIS
DOSE-RESPONSE ANALYSIS OF INFANTS PRENATALLY EXPOSED TO METHYL MERCURY - AN APPLICATION OF A SINGLE COMPARTMENT MODEL TO SINGLE-STRAND HAIR ANALYSIS
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DOI：
10.1016/s0013-9351(89)80075-1
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发表时间：
1989-08-01
影响因子：
8.3
通讯作者：
MYERS, GG
中科院分区：
文献类型：
--
作者：
COX, C;CLARKSON, TW;MYERS, GG
A new method of estimating fetal exposure is used in a dose-response analysis of data from the 1971 outbreak of methyl mercury poisoning in rural Iraq. An X-ray fluorescence instrument for the measurement of single strands of human hair was employed to obtain logitudinal profiles recapitulating fetal exposure. Logit and hockey-stick models as well as nonparametric smoothing are used to described data on delayed development and central nervous system abnormality.
