Cryptic Leishmaniosis by Leishmania infantum, a feature of canines only? A study of natural infection in wild rabbits, humans and dogs in southeastern Spain
Cryptic Leishmaniosis by Leishmania infantum, a feature of canines only? A study of natural infection in wild rabbits, humans and dogs in southeastern Spain
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DOI：
10.1016/j.vetpar.2011.04.016
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发表时间：
2011-09-08
影响因子：
2.6
通讯作者：
Berriatua, E.
中科院分区：
文献类型：
--
作者：
Chitimia, L.;Munoz-Garcia, C. I.;Berriatua, E.
进行了流行病学研究，调查无症状的婴儿利什曼原虫感染的PCR和ELISA在西班牙东南部的野兔，人类和家犬。兔血清阳性率为0%（0/36），人血清阳性率为2%（13/657），犬血清阳性率为7%（14/208）。在广泛的组织样本中检测的家兔中PCR阳性的发生率为0.6%（1/162），在血液样本中分析的人中为2%（8/392），在血液和淋巴组织样本中分析的犬中分别为10%（20/193）和67%（29/43）。结果表明，野兔有一个非常低的风险成为慢性感染L。infantum，并进一步证明了L.婴儿感染广泛存在于家养狗群中，并且也存在于相对较小比例的健康人中。这些研究结果的流行病学和临床意义进行了讨论。(C)2011 Elsevier B. V.保留所有权利。
An epidemiological study was carried out to investigate asymptomatic Leishmania infantum infection by PCR and ELISA in wild rabbits, humans and domestic dogs in southeastern Spain. Seroprevalence was 0% (0/36) in rabbits, 2% (13/657) in humans and 7% (14/208) in dogs. The prevalence of PCR-positives was 0.6% (1/162) in rabbits tested in a wide range of tissue samples, 2% (8/392) in humans analysed in blood samples and 10% (20/193) and 67% (29/43) in dogs analysed in blood and lymphoid tissue samples, respectively. Results suggest that wild rabbits have a very low risk of becoming chronically infected with L. infantum, and provide further evidence that cryptic L. infantum infection is widespread in the domestic dog population and is also present in a comparatively smaller proportion of healthy humans. The epidemiological and clinical implications of these findings are discussed. (C) 2011 Elsevier B.V. All rights reserved.