MR diffusion tensor imaging and fiber tracking in spinal cord arteriovenous malformations: A preliminary study
MR diffusion tensor imaging and fiber tracking in spinal cord arteriovenous malformations: A preliminary study
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DOI：
10.3174/ajnr.a0541
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发表时间：
2007-08-01
影响因子：
3.5
通讯作者：
Lasjaunias, P.
中科院分区：
文献类型：
--
作者：
Ozanne, A.;Krings, T.;Lasjaunias, P.
背景和目的：对脊髓动静脉畸形（AVM）患者的脊髓进行了扩散张量成像（DTI），以评价这种新技术确定脊髓束移位的可行性，并将形态和功能DTI数据相关联（各向异性分数[FA]和表观扩散系数[ADC]）与临床症状的关系。9例脊髓AVIVIs患者在1.5T下使用a.矢状面自旋回波单次激发回波平面广义自动校准部分平行采集弥散加权成像序列，计算不同感兴趣区域（病灶上方和下方）的ADC和FA图，并使用纤维束成像显示纤维束的路线。数据与临床症状，并与12名健康对照subjects.Results：在病灶的水平，管道是正常的，移位，分离，或中断，但不与病灶混合。束的中断与临床症状一致。在严重的神经功能缺损的患者，FA值尾侧的病灶表现出减少的各向异性符合损失的白色matter tracts.CONCLUSIONS：我们表明，AVM可能会中断，位移，或分离的纤维束和临床症状可以反映定量FA的结果和形态学损失的纤维远离病变。纤维追踪的DTI为脊髓AVM的成像提供了一种新的方法，并可能为了解这些病变的复杂病理生理学打开一扇窗。
BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) of the spinal cord in patients harboring spinal artenovenous malformations (AVMs) was carried out to evaluate the feasibility of this new technique to determine the displacement of the spinal cord tracts and to correlate morphologic and functional DTI data (fractional anisotropy [FA] and apparent diffusion coefficient [ADC]) with the clinical symptoms.MATERIALS AND METHODS: Nine patients with spinal cord AVIVIs were investigated at 1.5T using a. sagittal spin-echo single-shot echo-planar generalized autocalibrating partially parallel acquisition diffusion-weighted imaging sequence, ADC and FA maps were computed in different regions of interest (both above and below the nidus), and tractography was used to visualize the course of the tracts. The data were correlated with the clinical symptoms and compared with 12 healthy control subjects.RESULTS: At the level of the nidus, tracts were normal, shifted, separated, or interrupted but not intermingled with the nidus. Interruption of the tracts was coherent with the clinical symptoms. In patients with severe neurologic deficits, FA values caudal to the nidus showed a reduced anisotropy consistent with loss of white matter tracts.CONCLUSIONS: We demonstrate that AVMs may interrupt, displace, or separate the fiber tracts and that clinical symptoms may be reflected by the quantitative FA results and the morphologic loss of fibers distant to the lesion. DTI with fiber tracking offers a novel approach to image spinal cord AVMs and may open a window to understand the complex pathophysiology of these lesions.