Effect of kainic acid upon N1 latency
Effect of kainic acid upon N1 latency
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红藻氨酸对 N1 潜伏期的影响
DOI：
10.1288/00005537-198410000-00019
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
N. Inamura
中科院分区：
文献类型：
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作者：
J. Kusakari;E. Arakawa;K. Ohyama;M. Rokugo;N. Inamura
虽然全神经动作电位N1潜伏期是ECochG获得的重要信息之一，但对于其是否在感音神经性耳聋中延长存在一些相互矛盾的观点。红藻氨酸（KA）是已知的破坏神经元选择性地通过行动在神经元突触。因此，用KA溶液灌流鼓阶，制成“神经性耳聋”模型。KA对耳蜗微音电位的影响很小。KA对N1波幅有明显抑制作用，但对N1潜伏期无明显影响。本研究的结果有力地表明，N1潜伏期在“神经性耳聋”中没有延长。
Although the N1 latency of whole nerve action potential is one of the important pieces of information obtained from ECochG, there are some conflicting opinions as to whether or not it is prolonged in scnsorineural hearing loss. Kainic acid (KA) is known to destroy neurons selectively through an action at glutamatergic synapses. Therefore, a model of “neural deafness” was made by perfusing the scala tympani with KA solution. The effect of KA upon cochlear microphonics was minimal. Although the N1 amplitude was markedly suppressed by KA, the N1 latency was neither prolonged nor shortened. The result obtained in the present study strongly suggests that the N1 latency is not prolonged in “neural deafness.”