Spatial and non-spatial learning in turtles:: the role of medial cortex
Spatial and non-spatial learning in turtles:: the role of medial cortex
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DOI：
10.1016/s0166-4328(03)00030-5
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发表时间：
2003-08-14
影响因子：
2.7
通讯作者：
Salas, C
中科院分区：
文献类型：
--
作者：
López, JC;Vargas, JP;Salas, C
在哺乳动物和鸟类中，海马的处理对于异中心空间学习至关重要。在这些脊椎动物群体中，海马结构的病变在需要编码环境特征之间的关系的空间任务中产生选择性损伤，但在需要接近单一线索或简单的非空间歧视的任务中不产生选择性损伤。在爬行动物中，大量的解剖学证据表明，内侧皮层（MC）可能是同源的哺乳动物和鸟类的海马，然而，很少有研究已经检查了这个结构的功能作用，学习和记忆过程。这项工作的目的是研究如何MC病变影响空间策略。实验1的结果表明，MC损伤损害的性能在一个地方任务的动物手术前训练，虽然这些动物能够学习相同的任务手术后，探测测试显示，MC损伤的海龟使用的学习策略是不同的假手术动物。实验2表明，MC病变不损害保留的术前学习任务时，一个单一的intramaze视觉线索确定的目标。这些结果表明，哺乳动物和鸟类的爬行动物MC和海马的功能非常相似，不仅与受损的空间功能有关，而且与未受影响的学习过程有关。(C)2003 Elsevier Science B.V.保留所有权利。
In mammals and birds, hippocampal processing is crucial for allocentric spatial learning. In these vertebrate groups, lesions to the hippocampal formation produce selective impairments in spatial tasks that require the encoding of relationships among environmental features, but not in tasks that require the approach to a single cue or simple non-spatial discriminations. In reptiles, a great deal of anatomical evidence indicates that the medial cortex (MC) could be homologous to the hippocampus of mammals and birds; however, few studies have examined the functional role of this structure in relation to learning and memory processes. The aim of this work was to study how the MC lesions affect spatial strategies. Results of Experiment 1 showed that the MC lesion impaired the performance in animals pre-operatively trained in a place task, and although these animals were able to learn the same task after surgery, probe test revealed that learning strategies used by MC lesioned turtles were different to that observed in sham animals. Experiment 2 showed that the MC lesion did not impair the retention of the pre-operatively learned task when a single intramaze visual cue identified the goal. These results suggest that the reptilian MC and hippocampus of mammals and birds function in quite similar ways, not only in relation to those spatial functions that are impaired, but also in relation to those learning processes that are not affected. (C) 2003 Elsevier Science B.V. All rights reserved.