Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs
Impact of the calculation algorithm on biexponential fitting of diffusion-weighted MRI in upper abdominal organs
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DOI：
10.1002/mrm.25765
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发表时间：
2016-05-01
影响因子：
3.3
通讯作者：
Thoeny, Harriet C.
中科院分区：
文献类型：
--
作者：
Barbieri, Sebastiano;Donati, Olivio F.;Thoeny, Harriet C.
目的比较计算上腹部器官体素内非相干运动相关参数的6种不同算法(Levenberg-MarQuardt算法、信赖域算法、固定D-p算法、分段无约束算法、分段约束算法和贝叶斯概率算法)的可变性、精确度和准确性。方法在采集10例健康男性腹部弥散加权磁共振图像后，使用6种不同算法计算左、右肝、胰腺、脾、肾皮质和肾髓的体素内非相干运动相关参数。就读者间和学科间的可变性对算法进行了评估。结果的可比性通过方差分析进行评估。结果基于贝叶斯概率的方法具有很低的组间变异(组内平均相关系数为96.5~99.6%)，最低的受试者间变异(纯扩散系数D-t的变异系数[CV]：肾髓质3.8%，肾皮质6.6%，左右肝10.4~12.1%，脾15.3%，胰腺15.8%；灌注分数F-p平均15.5%；伪扩散系数D-p平均为25.8%)，精密度和准确度最高。结果差异有统计学意义(P
PurposeTo compare the variability, precision, and accuracy of six different algorithms (Levenberg-Marquardt, Trust-Region, Fixed-D-p, Segmented-Unconstrained, Segmented-Constrained, and Bayesian-Probability) for computing intravoxel-incoherent-motion-related parameters in upper abdominal organs.MethodsFollowing the acquisition of abdominal diffusion-weighted magnetic resonance images of 10 healthy men, six distinct algorithms were employed to compute intravoxel-incoherent-motion-related parameters in the left and right liver lobe, pancreas, spleen, renal cortex, and renal medulla. Algorithms were evaluated regarding inter-reader and intersubject variability. Comparability of results was assessed by analyses of variance. The algorithms' precision and accuracy were investigated on simulated data.ResultsA Bayesian-Probability based approach was associated with very low inter-reader variability (average Intraclass Correlation Coefficients: 96.5-99.6%), the lowest inter-subject variability (Coefficients of Variation [CV] for the pure diffusion coefficient D-t: 3.8% in the renal medulla, 6.6% in the renal cortex, 10.4-12.1% in the left and right liver lobe, 15.3% in the spleen, 15.8% in the pancreas; for the perfusion fraction F-p: 15.5% on average; for the pseudodiffusion coefficient D-p: 25.8% on average), and the highest precision and accuracy. Results differed significantly (P