Origins and Genetic Legacy of Neolithic Farmers and Hunter-Gatherers in Europe
Origins and Genetic Legacy of Neolithic Farmers and Hunter-Gatherers in Europe
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DOI：
10.1126/science.1216304
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发表时间：
2012-04-27
期刊：
影响因子：
56.9
通讯作者：
Jakobsson, Mattias
中科院分区：
文献类型：
--
作者：
Skoglund, Pontus;Malmstrom, Helena;Jakobsson, Mattias
农耕生活方式起源于大约11000年前的近东，5000年后传播到欧洲大陆的大部分地区。然而，农业革命对欧洲人口统计学和基因组变异模式的影响仍然未知。我们从斯堪的纳维亚半岛出土的三名狩猎采集者和一名农民5000年前的遗骸中获得了2.49亿碱基对的基因组DNA，发现这名农民在基因上与现存的南欧人最相似，这与狩猎采集人形成了鲜明的对比，后者独特的基因特征与现存的北欧人最相似。我们的结果表明，来自南欧的移民促进了农业的传播，这种扩张之后的混合最终塑造了现代欧洲的基因组图景。
The farming way of life originated in the Near East some 11,000 years ago and had reached most of the European continent 5000 years later. However, the impact of the agricultural revolution on demography and patterns of genomic variation in Europe remains unknown. We obtained 249 million base pairs of genomic DNA from similar to 5000-year-old remains of three hunter-gatherers and one farmer excavated in Scandinavia and find that the farmer is genetically most similar to extant southern Europeans, contrasting sharply to the hunter-gatherers, whose distinct genetic signature is most similar to that of extant northern Europeans. Our results suggest that migration from southern Europe catalyzed the spread of agriculture and that admixture in the wake of this expansion eventually shaped the genomic landscape of modern-day Europe.