Bayesian shadows of molecular mechanisms cast in the light of evolution.
Bayesian shadows of molecular mechanisms cast in the light of evolution.
复制标题
分子机制的贝叶斯阴影在进化的光下投射出来。
DOI：
10.1016/j.tibs.2006.05.002
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发表时间：
2006
影响因子：
13.8
通讯作者：
Neuwald,AndrewF
中科院分区：
文献类型：
--
作者：
Neuwald,AndrewF
A great many carefully designed experiments will be required to fully understand biological mechanisms in atomic detail. A complementary approach is to use powerful statistical procedures to rapidly test numerous scientific hypotheses using vast numbers of protein sequences – the cell's own blueprints for specifying biological mechanisms. Bayesian inference of the evolutionary constraints imposed on functionally divergent proteins can reveal key components of the molecular machinery and thereby suggest likely mechanisms to test experimentally. This approach is demonstrated by considering how DNA polymerase clamp-loader AAA+ATPases couple DNA recognition to ATP hydrolysis and clamp loading.
