The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges
The Research Domain Criteria (RDoC): An analysis of methodological and conceptual challenges
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DOI：
10.1016/j.brat.2014.07.019
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发表时间：
2014-11-01
影响因子：
4.1
通讯作者：
Lilienfeld, Scott O.
中科院分区：
文献类型：
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作者：
Lilienfeld, Scott O.
为了解决《诊断与统计手册》（DSM）框架在精神病理学分类和诊断方面长期存在的缺陷，美国国家精神卫生研究所（National Institute of Mental Health）最近发起了一项研究计划——研究领域标准（RDoC）——希望开发一种基于功能失调的脑回路的替代性分类系统。尽管RDoC的努力具有相当大的前景，但它面临着一些方法和概念上的挑战，我在这里提出其中的四个挑战：(a)过度强调生物单位和测量，(b)忽视测量误差，(c)内表型的生物学和心理测量限制，以及(d)生物倾向与其行为表现之间的区别。因为这些挑战在原则上都不是不可克服的，所以我鼓励研究人员考虑潜在的补救措施。RDoC是一场经过深思熟虑的赌博，似乎值得冒险，但它成功的机会将最大化，因为它需要深思熟虑地考虑过去几十年心理学和精神病学研究中来之不易的经验教训，而这些教训往往被遗忘。(C) 2014 Elsevier Ltd.版权所有。
In a bold effort to address the longstanding shortcomings of the Diagnostic and Statistical Manual (DSM) framework for the classification and diagnosis of psychopathology, the National Institute of Mental Health recently launched a research program - the Research Domain Criteria (RDoC) - in the hopes of developing an alternative taxonomic system rooted in dysfunctional brain circuitry. Although the RDoC endeavor has considerable promise, it faces several methodological and conceptual challenges, four of which I address here: (a) an overemphasis On biological units and measures, (b) neglect of measurement error, (c) biological and psychometric limitations of endophenotypes, and (d) the distinction between biological predispositions and their behavioral manifestations. Because none of these challenges is in principle insurmountable, I encourage investigators to consider potential remedies for them. RDoC is a calculated gamble that appears to be worth the risk, but its chances of success will be maximized by a thoughtful consideration of hard-won lessons learned but frequently forgotten over the past several decades of psychological and psychiatric research. (C) 2014 Elsevier Ltd. All rights reserved.