IL6 AND ACUTE PHASE PLASMA-PROTEINS IN PERITONEAL-FLUID OF WOMEN WITH ENDOMETRIOSIS
IL6 AND ACUTE PHASE PLASMA-PROTEINS IN PERITONEAL-FLUID OF WOMEN WITH ENDOMETRIOSIS
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DOI：
10.1016/0009-8981(92)90204-4
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发表时间：
1992-09-30
影响因子：
5
通讯作者：
DURAND, G
中科院分区：
文献类型：
--
作者：
BOUTTEN, A;DEHOUX, M;DURAND, G
几位作者记录了子宫内膜异位症妇女盆腔慢性炎症的迹象。我们通过测量白细胞介素6（IL 6）和蛋白质的水平，研究了白细胞介素6（IL 6）（炎症和免疫的重要调节因子）可能参与轻微和轻度子宫内膜异位症（α 1-酸性糖蛋白，α 1-抗胰蛋白酶，α 2-HS糖蛋白和白蛋白），其合成受IL 6调节，来自组织学证实的子宫内膜异位症不孕妇女的腹膜液（PF）（I期和II期; n = 28）和来自无子宫内膜异位症的生育妇女（n = 14）和不孕妇女（n = 13）。还研究了子宫内膜异位症（n = 12）和非子宫内膜异位症（n = 9）妇女培养的PF巨噬细胞的自发和LPS诱导的IL 6分泌。在研究的四种蛋白质的浓度中未观察到显著差异。免疫反应性IL 6在所有三组中均检测到，无显著差异。相比之下，子宫内膜异位症患者未经刺激（P = 0.01）和经LPS刺激（P = 0.006）的腹腔巨噬细胞释放的IL 6水平显著较高。我们的结论是，局部IL-6的合成活化的巨噬细胞可能在子宫内膜异位症的过程中发挥作用。
Several authors have documented signs of chronic inflammation in the pelvis of women with endometriosis. We investigated the possible involvement of interleukin 6 (IL6), an important regulator of inflammation and immunity, in minimal and mild endometriosis by measuring levels of IL6 and proteins (alpha1-acid glycoprotein, alpha1-antitrypsin, alpha2-HS glycoprotein and albumin) the synthesis of which is regulated by IL6, in peritoneal fluid (PF) from infertile women with histologically confirmed endometriosis (stage I and II; n = 28) and from endometriosis-free fertile (n = 14) and infertile women (n = 13). Spontaneous and LPS-induced IL6 secretion by cultured PF macrophages from women with endometriosis (n = 12) and without endometriosis (n = 9) were also studied. No significant differences were observed in the concentrations of the four proteins studied. Immunoreactive IL6 was detected in all three groups, with no significant differences. In contrast, significantly higher levels of IL6 were released by both unstimulated (P = 0.01) and LPS-stimulated (P = 0.006) peritoneal macrophages from the women with endometriosis. We conclude that local IL6 synthesis by activated macrophages may play a role in the endometriosis process.