Spike Timing-Dependent Plasticity in CA1 Pyramidal Neuron-Controlling Hippocampal Circuits: a Model Study
Spike Timing-Dependent Plasticity in CA1 Pyramidal Neuron-Controlling Hippocampal Circuits: a Model Study
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CA1 锥体神经元控制海马回路中尖峰时间依赖性可塑性：模型研究
DOI：
10.1007/s11062-014-9448-z
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发表时间：
2014
期刊：
影响因子：
0.5
通讯作者：
Yi Zeng
中科院分区：
文献类型：
--
作者：
H. Ren;Shenquan Liu;X. Zhang;Yi Zeng
尖峰时间依赖性可塑性（STDP）在塑造海马中存储信息的神经回路中起着重要作用，因为运动学习和记忆被认为与这种类型的突触可塑性密切相关。我们建立了一个计算模型，通过线性改变突触的权重和数量来研究潜在的学习规则。结果表明：（1）突触重量和突触数目的改变可导致突触效能的不同长期变化：（2）两个神经元的第一个锋电位对对随后的锋电位对有很大影响，前-后锋电位对加强随后的成对锋电位，而后-前锋电位对抑制该成对锋电位;（iii）当突触权重和突触数目改变时，第一尖峰对中的间隔减小，这直接影响第一尖峰对，以及（iv）当星状神经元受到弱刺激或CA 1锥体神经元的电容减小时，LTP比LTD更容易产生;在相反的情况下，LTD更容易产生;突触数量的增加可以促进CA 1锥体神经元的激活。
Spike timing-dependent plasticity (STDP) plays an important role in sculpting neural circuits to store information in the hippocampus, since motor learning and memory are thought to be closely linked with this type of synaptic plasticity. We built a computational model to study the potential learning rule by linearly changing the synaptic weight and number of the synapses involved. The main findings are the following: (i) changes in the synaptic weight and number of synapses can lead to different long-term changes in the synaptic efficacy; (ii) the first spike pair of two neurons exerts a great influence on the subsequent spike pair; a pre-post spiking pair reinforces the subsequent paired spiking, while a post-pre spiking pair depresses this paired spiking; (iii) when the synaptic weight and synaptic number change, the interval in the first spiking pair is reduced, which directly influences the first spiking pair, and (iv) when a stellate neuron is stimulated weakly or the capacitance of a CA1 pyramidal neuron is decreased, LTP is produced more easily than LTD; in the opposite case, LTD is produced more readily; an increase of the synaptic number can promote activation of CA1 pyramidal neurons.