Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
复制标题
DOI：
10.1038/oby.2008.318
复制
发表时间：
2008-08-01
期刊：
影响因子：
6.9
通讯作者：
Johnstone, Alexandra M.
中科院分区：
文献类型：
--
作者：
Speakman, John R.;Rance, Kellie A.;Johnstone, Alexandra M.
FTO基因具有与肥胖相关的显着多态性变异，但其功能尚不清楚。我们对居住在英国苏格兰东北部的 150 名白人 (103F/47M) 进行了筛查，寻找 FTO 基因的变异，并将这些变异与他们的能量消耗（基础代谢率 (BMR) 和最大耗氧量 VO(2)max）和能量摄入的表型变异联系起来。 FTO 基因型与 BMR 或 VO(2)max 之间没有显着相关性。 FTO 基因型与能量摄入变化显着相关（P = 0.024），野生型 TT 基因型的平均每日摄入量为 9.0 MJ，“危险”AT 和 AA 基因型的平均每日摄入量分别为 10.2 和 9.5 MJ。调整 BMR 摄入量并没有消除显着性（P = 0.043）。 FTO 基因型可能通过影响食物摄入而不是能量消耗来影响肥胖。
The FTO gene has significant polymorphic variation associated with obesity, but its function is unknown. We screened a population of 150 whites (103F/47M) resident in NE Scotland, United Kingdom, for variants of the FTO gene and linked these to phenotypic variation in their energy expenditure (basal metabolic rate (BMR) and maximal oxygen consumption VO(2)max) and energy intake. There was no significant association between the FTO genotype and BMR or VO(2)max. The FTO genotype was significantly associated (P = 0.024) with variation in energy intake, with average daily intake being 9.0 MJ for the wild-type TT genotype and 10.2 and 9.5 MJ for the "at risk" AT and AA genotypes, respectively. Adjusting intake for BMR did not remove the significance (P = 0.043). FTO genotype probably affects obesity via effects on food intake rather than energy expenditure.