Prevalence of antibiotic resistance in Campylobacter isolates from commercial poultry suppliers in KwaZulu-Natal, South Africa
Prevalence of antibiotic resistance in Campylobacter isolates from commercial poultry suppliers in KwaZulu-Natal, South Africa
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DOI：
10.1093/jac/dkn408
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发表时间：
2008-12-01
影响因子：
5.2
通讯作者：
Essack, S. Y.
中科院分区：
文献类型：
--
作者：
Bester, L. A.;Essack, S. Y.
从南非夸祖鲁-纳塔尔注册屠宰场的肉鸡和蛋鸡中分离到空肠弯曲杆菌，用琼脂稀释法测定其对8种抗生素的敏感性，共分离到155株空肠弯曲菌，其中77株为空肠弯曲菌(肉鸡56只，蛋鸡21只)。对四环素(肉鸡98.2%，蛋鸡100%)和头孢曲松(96.4%，蛋鸡100%)的耐药率最高。对环丙沙星(肉鸡91%，蛋鸡76%)和庆大霉素(肉鸡98%，蛋鸡81%)的敏感性较高。肉鸡和蛋鸡对各种抗生素的敏感率分别为：红霉素50%和57%，克拉霉素45%和24%，氨苄西林68%和43%，%和萘啶酸48%。庆大霉素、环丙沙星和四环素对肉鸡和蛋鸡的最低抑菌浓度(MIC50)差异显著(P&0.001)，庆大霉素的MIC90也差异极显著(P=0.01)。肉鸡和蛋鸡分离株的多重耐药性分别为23%和43%。畜牧业中使用的大规模治疗方法对空肠弯曲菌耐药性的产生有潜在的影响。
Campylobacter jejuni isolated from broiler and layer chickens from registered abattoirs in KwaZulu-Natal, South Africa, were tested for their susceptibility to eight antibiotics.Using agar dilution, susceptibility to eight antibiotics was determined for C. jejuni recovered from the caeca.A total of 155 isolates were collected of which 77 were identified as C. jejuni (broilers n = 56 and layers n = 21). Resistance was highest to tetracycline (broilers 98.2% and layers 100%) and ceftriaxone (broilers 96.4% and layers 100%). High susceptibility was found to ciprofloxacin (broilers 91% and layers 76%) and gentamicin (broilers 98% and layers 81%). Susceptibilities to each of the antibiotics for the broilers and layers, respectively, were: 50% and 57% for erythromycin, 45% and 24% for clarithromycin, 68% and 43% for ampicillin and 64% and 48% for nalidixic acid. Statistically significant differences were detected for the MIC(50) of gentamicin, ciprofloxacin and tetracycline between broilers and layers (P < 0.001) with the MIC(90) of gentamicin also of significant difference (P = 0.01). Multiresistance was detected in 23% and 43% of the isolates from broiler and layer chickens, respectively.Mass therapy procedures used in animal husbandry have a potential impact on antibiotic resistance development in C. jejuni.