Inhibition of leukocyte adhesion by developmental endothelial locus-1 (del-1).
Inhibition of leukocyte adhesion by developmental endothelial locus-1 (del-1).
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DOI：
10.4110/in.2009.9.5.153
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发表时间：
2009-10-01
期刊：
影响因子：
6
通讯作者：
Choi, Eun Young
中科院分区：
文献类型：
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作者：
Choi, Eun Young
白细胞粘附于内皮细胞在炎症、自身免疫和感染性疾病期间发生的白细胞募集中是关键的。白细胞和内皮细胞之间的相互作用需要在白细胞和内皮细胞上表达的粘附分子阵列，从而促进白细胞募集到炎症和组织损伤部位。粘附分子的干预为开发抗炎治疗提供了平台。本文就发育性内皮细胞位点-1（Del-1），一种内源性白细胞粘附抑制剂的研究进展作一综述。
The leukocyte adhesion to endothelium is pivotal in leukocyte recruitment which takes place during inflammatory, autoimmune and infectious conditions. The interaction between leukocytes and endothelium requires an array of adhesion molecules expressed on leukocytes and endothelial cells, thereby promoting leukocyte recruitment into sites of inflammation and tissue injury. Intervention with the adhesion molecules provides a platform for development of anti-inflammatory therapeutics. This review will focus on developmental endothelial locus-1 (Del-1), an endogenous inhibitor of leukocyte adhesion.