Structural equation modeling of sleep apnea, inflammation, and metabolic dysfunction in children
Structural equation modeling of sleep apnea, inflammation, and metabolic dysfunction in children
复制标题
DOI：
10.1111/j.1365-2869.2007.00614.x
复制
发表时间：
2007-12-01
影响因子：
4.4
通讯作者：
Baur, Louise A.
中科院分区：
文献类型：
--
作者：
Waters, Karen A.;Mast, Benjamin T.;Baur, Louise A.
阻塞性睡眠呼吸暂停（OSA），通常伴随着肥胖，增加了代谢综合征的风险。可能参与这种关联的一种机制是炎症途径的上调。我们使用结构方程模型来评估儿童肥胖、OSA、炎症和代谢功能障碍之间的相互关系。184名儿童（127名男孩，平均年龄：8.5 ± 4.1岁）测量了身高和体重，进行了夜间多导睡眠图检查，并采集了空腹血液。分析血液中的胰岛素、葡萄糖、脂质、瘦素和细胞因子[干扰素（IFN）-γ、粒细胞巨噬细胞集落刺激因子、白细胞介素（IL）-1 β、IL-2、IL-4、IL-6、IL-8、IL-10、IL-12、肿瘤坏死因子-α]。使用结构方程模型（SEM）评价关注的结局之间的相关性，包括缺氧、觉醒（与呼吸和自发性相关）、肥胖、代谢功能障碍和炎症标志物。两个细胞因子和一个代谢因子的SEM。这些因素在结构方程模型中提供了良好的拟合（chi（2）/df = 2.855;比较拟合指数= 0.90，近似均方根误差= 0.10），并且所有因素负荷均与零有显著差异（P
Obstructive sleep apnea (OSA), often concomitant with obesity, increases the risk for the metabolic syndrome. One mechanism that may participate in this association is upregulation of inflammatory pathways. We used structural equation modeling to assess the interrelations between childhood obesity, OSA, inflammation, and metabolic dysfunction. One hundred and eighty-four children (127 boys, mean age: 8.5 +/- 4.1years) had height and weight measured, underwent overnight polysomnography and had fasting blood taken. The blood was analyzed for insulin, glucose, lipids, leptin, and cytokines [interferon (IFN)-gamma, granulocyte macrophage-colony stimulating factor, interleukin (IL)-1 beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor-alpha]. Structural equation modeling (SEM) was used to evaluate associations between the outcomes of interest including hypoxia, arousal (related to respiratory and spontaneous), obesity, metabolic dysfunction, and inflammatory markers. Two cytokine factors and one metabolic factor were derived for the SEM. These factors provided good fit in the structural equation model (chi(2)/df = 2.855; comparative fit index = 0.90, root mean squared error of approximation = 0.10) and all factor loadings were significantly different from zero (P