Interneuron migration from basal forebrain to neocortex: Dependence on Dlx genes
Interneuron migration from basal forebrain to neocortex: Dependence on Dlx genes
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DOI：
10.1126/science.278.5337.474
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发表时间：
1997-10-17
期刊：
影响因子：
56.9
通讯作者：
Rubenstein, JLR
中科院分区：
文献类型：
--
作者：
Anderson, SA;Eisenstat, DD;Rubenstein, JLR
尽管之前的分析表明新皮质神经元起源于皮质增殖区，但有证据表明新皮质中间神经元的一个亚群起源于皮质下端脑。例如，表达γ-氨基丁酸（GABA）的细胞在体外从皮质下端脑迁移到新皮质。通过将新皮质与皮质下端脑分离，可以减少新皮质切片中表达 GABA 的细胞数量。最后，缺乏同源结构域蛋白DLX-1和DLX-2的小鼠没有表现出可检测到的从皮质下端脑到新皮质的细胞迁移，并且新皮质中也有很少的表达GABA的细胞。
Although previous analyses indicate that neocortical neurons originate from the cortical proliferative zone, evidence suggests that a subpopulation of neocortical interneurons originates within the subcortical telencephalon. For example, gamma-aminobutyric acid (GABA)-expressing cells migrate in vitro from the subcortical telencephalon into the neocortex. The number of GABA-expressing cells in neocortical slices is reduced by separating the neocortex from the subcortical telencephalon. Finally, mice lacking the homeodomain proteins DLX-1 and DLX-2 show no detectable cell migration from the subcortical telencephalon to the neocortex and also have few GABA-expressing cells in the neocortex.