Ultrasensitive Fluorescent Detection of Tetracycline Based on Selective Supramolecular Interaction of Nitrogen Chlorine Co-Doped Graphene Quantum Dots
Ultrasensitive Fluorescent Detection of Tetracycline Based on Selective Supramolecular Interaction of Nitrogen Chlorine Co-Doped Graphene Quantum Dots
复制标题
基于氮氯共掺杂石墨烯量子点选择性超分子相互作用的四环素超灵敏荧光检测
DOI：
10.1002/slct.202000816
复制
发表时间：
2020-06-30
期刊：
影响因子：
2.1
通讯作者：
Wang, Gang
中科院分区：
文献类型：
--
作者：
Gu, Bingli;Chen, Da;Wang, Gang
本文提出了一种利用柠檬酸和3，4-二氯苯胺通过水热处理制备氮氯共掺石墨烯量子点(N，Cl-GQD)的简单方法，并建立了检测四环素的荧光传感器。这些合成的N，Cl-GQD主要由1-3层组成，平均尺寸约为4.5 nm。在365 nm紫外光照射下，得到的N，Cl-GQD具有较强的蓝色荧光，量子产率为23.2%。系统的研究表明，N，Cl-GQD具有激发无关发射、高单分散性、良好的稳定性和水溶性等优良特性。此外，加入少量四环素可显著猝灭N，Cl-GQD的荧光强度。最后证明了一种检测四环素的荧光探针，其检测下限为68 nm，在生物传感器和生物成像方面具有很大的潜力。
Herein, a simple bottom-up method for producing nitrogen and chlorine co-doped graphene quantum dots (N, Cl-GQDs) was proposed by utilizing citric acid and 3,4-dichloroaniline via hydrothermal treatment, and a fluorescent sensor for the detection of tetracycline was demonstrated. These synthesized N, Cl-GQDs consist mostly of 1-3 layers with a uniform size of about 4.5 nm. Strong blue fluorescence with a quantum yield of 23.2 % was observed from the obtained N, Cl-GQDs when irradiated with a 365 nm UV light. Systematic studies indicate that N, Cl-GQDs have several superior features, including excitation-independent emission, high monodispersity, good stability and water solubility. Moreover, the fluorescence intensity of N, Cl-GQDs could be significantly quenched by the addition of a small amount of tetracycline. Finally, a fluorescent probe for the detection of tetracycline with a detection limit of 68 nM was proved, which exhibits great potentials for biosensors and biological imaging.