The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas.
The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas.
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DOI：
10.1182/blood.v93.11.3601.411a47_3601_3609
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发表时间：
1999-06
期刊：
影响因子：
20.3
通讯作者：
J. Dierlamm;M. Baens;I. Wlodarska;Margarita Stefanova-Ouzounova;J. Hernández;D. Hossfeld;C. Wolf‐peeters;A. Hagemeijer;H. V. D. Berghe;P. Marynen
中科院分区：
文献类型：
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作者：
J. Dierlamm;M. Baens;I. Wlodarska;Margarita Stefanova-Ouzounova;J. Hernández;D. Hossfeld;C. Wolf‐peeters;A. Hagemeijer;H. V. D. Berghe;P. Marynen
粘膜相关淋巴组织边缘区细胞淋巴瘤是发生于淋巴结部位的最常见的淋巴瘤亚型。t（11;18）（q21;q21）似乎是关键的遗传病变，在大约50%的细胞遗传学异常的低度MALT淋巴瘤中发现。我们发现，API 2基因，编码一种细胞凋亡抑制剂，也被称为c-IAP 2，HIAP 1，和MIHC，和一个新的基因在18 q21上的特点是几个Ig样C2型结构域，命名为MLT，在t（11;18）中反复重排。在分析的两种MALT淋巴瘤中，API 2中的断裂点发生在分别编码杆状病毒IAP重复结构域和胱天蛋白酶募集结构域的外显子的内含子中。在两种情况下，MLT内的断点不同，但开放阅读框架是保守的。在一种情况下，易位伴随着涉及API 2的3'部分的隐蔽缺失。结果，不存在相互转录物，强烈提示API 2-MLT融合参与MALT淋巴瘤的肿瘤发生。
Marginal zone cell lymphomas of the mucosa-associated lymphoid tissue (MALT) are the most common subtype of lymphoma arising at extranodal sites. The t(11;18)(q21;q21) appears to be the key genetic lesion and is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphomas. We show that the API2 gene, encoding an inhibitor of apoptosis also known as c-IAP2, HIAP1, and MIHC, and a novel gene on 18q21 characterized by several Ig-like C2-type domains, named MLT, are recurrently rearranged in the t(11;18). In both MALT lymphomas analyzed, the breakpoint in API2 occurred in the intron separating the exons coding respectively for the baculovirus IAP repeat domains and the caspase recruitment domain. The breakpoints within MLT differed but the open reading frame was conserved in both cases. In one case, the translocation was accompanied by a cryptic deletion involving the 3' part of API2. As a result, the reciprocal transcript was not present, strongly suggesting that the API2-MLT fusion is involved in the oncogenesis of MALT lymphoma.