Induced chromosomal proximity and gene fusions in prostate cancer.
Induced chromosomal proximity and gene fusions in prostate cancer.
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DOI：
10.1126/science.1178124
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发表时间：
2009-11-27
期刊：
影响因子：
--
通讯作者：
Chinnaiyan AM
中科院分区：
文献类型：
--
作者：
Mani RS;Tomlins SA;Callahan K;Ghosh A;Nyati MK;Varambally S;Palanisamy N;Chinnaiyan AM
基因融合在癌症进展中具有关键作用。与这些融合的发生和细胞类型特异性相关的机制还不清楚。原型基因融合TMPRSS 2-ERG涉及雄激素调节基因TMPRSS 2的5'非翻译区与ERG基因，并且是与前列腺癌相关的最常见的基因融合。我们证明，雄激素信号诱导TMPRSS 2和ERG基因座之间的染色体接近，并促进TMPRSS 2-ERG基因融合的形成时，受到的代理，导致DNA双链断裂。这些结果为基因融合的发生提供了概念框架，并可能为人类前列腺癌的一般病因提供建议。
Gene fusions have a critical role in cancer progression. Mechanisms associated with the genesis and cell type specificity of these fusions are not well understood. A prototypical gene fusion, TMPRSS2-ERG, involves the 5’ untranslated region of the androgen-regulated gene TMPRSS2 with the ERG gene, and is the most common gene fusion associated with prostate cancer. We demonstrate that androgen signaling induces chromosomal proximity between TMPRSS2 and ERG loci, and facilitates the formation of the TMPRSS2-ERG gene fusion when subjected to an agent that causes DNA double strand breaks. These results provide a conceptual framework for the genesis of gene fusions and may provide suggestions as to the general etiology of human prostate cancer.
影响因子：
56.9
作者：
Tomlins, SA;Rhodes, DR;Chinnaiyan, AM
通讯作者：
Chinnaiyan, AM
DOI：
10.1073/pnas.0810634105
发表时间：
2008-12-09
影响因子：
11.1
作者：
Hu, Qidong;Kwon, Young-Soo;Fu, Xiang-Dong
通讯作者：
Fu, Xiang-Dong
影响因子：
56.9
作者：
Nikiforova, MN;Stringer, JR;Nikiforov, YE
通讯作者：
Nikiforov, YE