AN INVESTIGATION OF CHANGES IN RELATIVE BIOLOGICAL EFFECTIVENESS (RBE) WITH DEPTH FOR X-RAY-BEAMS GENERATED BETWEEN 100 AND 250-KVP USING THE MOUSE FOOT AS BIOLOGICAL TEST SYSTEM
AN INVESTIGATION OF CHANGES IN RELATIVE BIOLOGICAL EFFECTIVENESS (RBE) WITH DEPTH FOR X-RAY-BEAMS GENERATED BETWEEN 100 AND 250-KVP USING THE MOUSE FOOT AS BIOLOGICAL TEST SYSTEM
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DOI：
10.1016/0360-3016(86)90041-6
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发表时间：
1986-05-01
影响因子：
7
通讯作者：
HERING, ER
中科院分区：
文献类型：
--
作者：
HERING, ER
对于早期小鼠足部皮肤反应，在表面和深度分别产生 100 至 250 kVp 的 X 射线束照射时，RBE 相对于 60Co 有所增加。在大多数情况下，表面和深度照射的晚期皮肤反应的 RBE 显着低于早期反应。讨论了这些结果的临床意义、皮肤细胞中可能缺氧部分的影响以及放射生物学实验的“标准”辐射方式的选择。
For the early mouse foot skin reactions an increase in RBE relative to 60Co has been found for the irradiations with X ray beams generated between 100 and 250 kVp at both the surface and depth, respectively. In most cases, the RBE of the late skin reactions for irradiations at the surface and at depth are significantly lower than those for the early reactions. The clinical implications of these results, the effect of a possible hypoxic fraction of cells in the skin, and the choice of a "standard" radiation modality for radiobiological experiments are discussed.