Long-Term Outcomes of SARS-CoV-2 Variants and Other Respiratory Infections: Evidence from the Virus Watch Prospective Cohort in England
Long-Term Outcomes of SARS-CoV-2 Variants and Other Respiratory Infections: Evidence from the Virus Watch Prospective Cohort in England
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SARS-CoV-2 变体和其他呼吸道感染的长期结果：来自英格兰病毒观察前瞻性队列的证据
DOI：
10.1101/2023.12.18.23300124
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Beale S
中科院分区：
文献类型：
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作者：
Beale S
这项研究比较了感染SARS-CoV-2变种、其他急性呼吸道感染(ARI)和未感染的人感染后长期后遗症的可能性。参与者(n=5,630)来自病毒观察，这是一个调查英国SARS-CoV-2流行病学的预期社区队列。通过Logistic回归，我们比较了根据感染状态(SARS-CoV-2、其他ARI或未感染)在不同的显性时期发生长期症状(>；2个月)的预测概率，并调整了人口统计学、临床因素和疫苗接种状况的混杂。早期至Omicron BA.1的SARS-CoV-2感染与较晚的Omicron亚型(PP范围为0.11，95%CI为0.08~0.15~0.14，95%CI为0.10~0.18)相比有更高的远期后遗症概率(调整后的预测概率(PP)范围为0.27，95%CI=0.22~0.33~0.34，95%CI=0.25~0.43)。虽然SARS-CoV-2与其他ARI之间的差异(PP范围为0.08，95%CI为0.04-0.11至0.23，95%CI为0.18-0.28)因时期而异，但所有感染后的估计值均显著高于未感染人群(PP范围为0.01，95%CI为0.00，0.02至0.03，95%CI为0.01-0.06)。变异是SARS-CoV-2感染后后遗症的重要预测因子，最近的OMICRON亚变异体显示出与其他同时代ARI相似的概率。建议进行进一步的病原学调查，包括病原体之间的比较。
This study compared the likelihood of long-term sequelae following infection with SARS-CoV-2 variants, other acute respiratory infections (ARIs) and non-infected individuals. Participants (n=5,630) were drawn from Virus Watch, a prospective community cohort investigating SARS-CoV-2 epidemiology in England. Using logistic regression, we compared predicted probabilities of developing long-term symptoms (>2 months) during different variant dominance periods according to infection status (SARS-CoV-2, other ARI, or no infection), adjusting for confounding by demographic and clinical factors and vaccination status. SARS-CoV-2 infection during early variant periods up to Omicron BA.1 was associated with greater probability of long-term sequalae (adjusted predicted probability (PP) range 0.27, 95% CI = 0.22–0.33 to 0.34, 95% CI = 0.25–0.43) compared with later Omicron sub-variants (PP range 0.11, 95% CI 0.08–0.15 to 0.14, 95% CI 0.10–0.18). While differences between SARS-CoV-2 and other ARIs (PP range 0.08, 95% CI 0.04–0.11 to 0.23, 95% CI 0.18–0.28) varied by period, all post-infection estimates substantially exceeded those for non-infected participants (PP range 0.01, 95% CI 0.00, 0.02 to 0.03, 95% CI 0.01–0.06). Variant was an important predictor of SARS-CoV-2 post-infection sequalae, with recent Omicron sub-variants demonstrating similar probabilities to other contemporaneous ARIs. Further aetiological investigation including between-pathogen comparison is recommended.