Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C
Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C
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DOI：
10.1016/j.cca.2010.02.063
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发表时间：
2010-05-02
影响因子：
5
通讯作者：
Yatomi, Yutaka
中科院分区：
文献类型：
--
作者：
Ikeda, Hitoshi;Ohkawa, Ryunosuke;Yatomi, Yutaka
背景资料：生物活性脂质介质S1P作为循环旁分泌介质，在临床科学的各个领域发挥着病理生理作用。我们以前建立了一个可靠的方法来测量血浆中的SIP浓度，并报告说，在健康受试者的一个有性别差异和红细胞（RBC）参数的相关性，然而，在血液中的S1P测量的报告与特定疾病的患者一直很少见。由于我们以前的证据表明，S1P参与肝脏病理生理，我们检查血浆S1P浓度在慢性丙型肝炎patients.Methods：SIP测定进行使用高效液相色谱system.Results：血浆S1P浓度降低慢性丙型肝炎患者相比，在健康受试者具有相同的血红蛋白浓度，不分性别。在血液参数中，血清透明质酸浓度（肝纤维化的替代标志物）与血浆SIP浓度最密切且呈负相关。此外，血浆SIP浓度下降的四氯化碳诱导的肝纤维化rats.Conclusions：血浆S1P浓度降低慢性丙型肝炎患者，肝纤维化可能参与，至少部分，在负责这种减少的机制。(C)2010 Elsevier B.V.保留所有权利。
Background: Bioactive lipid mediator S1P has been suggested to play pathophysiological roles in various fields of clinical science as a circulating paracrine mediator. We previously established a reliable method of measuring plasma SIP concentration, and reported that the one in healthy subjects has a gender difference and a correlation with red blood cell (RBC)-parameters, however, the reports of S1P measurements in the blood in patients with a specific disease have been scarce. Because our previous evidence suggests that S1P is involved in liver pathophysiology, we examined plasma S1P concentration in chronic hepatitis C patients.Methods: SIP assay was performed using a high-performance liquid chromatography system.Results: Plasma S1P concentrations were reduced in chronic hepatitis C patients compared with in healthy subjects with the same hemoglobin concentration, irrespective of gender. Among the blood parameters, serum hyaluronic acid concentration, a surrogate marker for liver fibrosis, was most closely and inversely correlated with plasma SIP concentration. Furthermore, plasma SIP concentration decreased throughout the progression of carbon tetrachloride-induced liver fibrosis in rats.Conclusions: Plasma S1P concentration was reduced in chronic hepatitis C patients, and liver fibrosis might be involved, at least in part, in the mechanism responsible for this reduction. (C) 2010 Elsevier B.V. All rights reserved.