Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform.
Enabling the democratization of the genomics revolution with a fully integrated web-based bioinformatics platform.
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DOI：
10.1093/nar/gkw1027
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发表时间：
2017-01-09
影响因子：
14.9
通讯作者：
Chain PS
中科院分区：
文献类型：
--
作者：
Li PE;Lo CC;Anderson JJ;Davenport KW;Bishop-Lilly KA;Xu Y;Ahmed S;Feng S;Mokashi VP;Chain PS
测序技术的持续进步推动了新测序应用的发展，并有望用原始数据淹没当前的数据库。许多因素阻碍了这些数据的无缝和轻松使用，包括项目目标的广度，单独执行任何给定分析的一部分的各种工具，大量相关的软件/硬件依赖关系，以及执行这些分析所需的详细专业知识。为了解决这些问题，我们开发了一个直观的基于网络的环境，在预配置的工作流程中提供了各种集成的尖端生物信息学工具。这些工作流程，加上环境的易用性，为新一代测序新手用户提供了只需点击几下鼠标即可执行许多复杂分析的能力，并在相同环境的背景下，可视化并进一步询问其结果。该生物信息学平台是在微生物研究的广泛应用中增强基因组学专业知识（EDGE）发展的初步尝试。
Continued advancements in sequencing technologies have fueled the development of new sequencing applications and promise to flood current databases with raw data. A number of factors prevent the seamless and easy use of these data, including the breadth of project goals, the wide array of tools that individually perform fractions of any given analysis, the large number of associated software/hardware dependencies, and the detailed expertise required to perform these analyses. To address these issues, we have developed an intuitive web-based environment with a wide assortment of integrated and cutting-edge bioinformatics tools in pre-configured workflows. These workflows, coupled with the ease of use of the environment, provide even novice next-generation sequencing users with the ability to perform many complex analyses with only a few mouse clicks and, within the context of the same environment, to visualize and further interrogate their results. This bioinformatics platform is an initial attempt at Empowering the Development of Genomics Expertise (EDGE) in a wide range of applications for microbial research.