Mono- and dinuclear gadolinium(III) complexes of tris(4-carboxy-3-benzyl-3-azabutyl) amine: Synthesis and relaxation properties
Mono- and dinuclear gadolinium(III) complexes of tris(4-carboxy-3-benzyl-3-azabutyl) amine: Synthesis and relaxation properties
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DOI：
10.1016/j.poly.2015.12.064
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发表时间：
2016-03-09
期刊：
影响因子：
2.6
通讯作者：
Ogawa, Akiya
中科院分区：
文献类型：
--
作者：
Makita, Yoshimasa;Inoue, Masashi;Ogawa, Akiya
在本研究中，合成了三(4-羧基-3-苄基-3-氮杂丁基)胺，一种新型聚氨基羧酸酯配体。还合成了两种新的钆与该配体的非离子络合物（单核络合物和双核络合物），作为潜在的磁共振成像（MRI）造影剂。通过X射线晶体结构分析确定了双核配合物的结构。评估了单核和双核复合物的弛豫性和细胞毒性。 (C) 2016 Elsevier Ltd. 保留所有权利。
In this study, tris(4-carboxy-3-benzyl-3-azabutyl) amine a novel polyaminocarboxylate ligand was synthesized. Two new nonionic complexes (a mononuclear complex and a dinuclear complex) of gadolinium with this ligand were also synthesized as potential magnetic resonance imaging (MRI) contrast agents. The structure of the dinuclear complex was determined by X-ray crystal structure analysis. The relaxivity and cytotoxicity of the mono- and dinuclear complexes were evaluated. (C) 2016 Elsevier Ltd. All rights reserved.