Effects of serotonin and some other neurohumoral agents on adrenergic neurotransmission in spontaneously hypertensive rat vasculature.
Effects of serotonin and some other neurohumoral agents on adrenergic neurotransmission in spontaneously hypertensive rat vasculature.
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DOI：
10.3109/10641968309069507
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
T. Kubo;C. Su
中科院分区：
文献类型：
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作者：
T. Kubo;C. Su
本实验观察了5-羟色胺（5-HT）、乙酰胆碱（ACh）、组胺和多巴胺对肠系膜血管升压反应的影响。本文比较了自发性高血压大鼠（SHR）和对照Wistar京都大鼠（WKY）对动脉周围交感神经刺激（NS，8Hz，2 msec，30 sec）和外源性去甲肾上腺素（NE，0.2nmol）的反应。在WKY和SHR中，ACh（3-30 nM）、组胺（0.3-3 μ M）和多巴胺（0.3 μ M）减弱NS诱导的血管收缩反应与NE诱导的反应一样多，表明突触后抑制占主导地位。5 HT（10-100 nM）增强WKY大鼠对NS的缩血管反应，其作用明显弱于NE，提示突触前抑制。SHR无此差异。这些结果提示，5-HT对SHR血管肾上腺素能神经传递的突触前抑制作用减弱，这可能与SHR血压升高有关。
The effects of serotonin (5HT), acetylcholine (ACh), histamine and dopamine on the pressor responses of the mesenteric vasculature were examined in view of their potential role in neuromodulation. The responses to periarterial sympathetic nerve stimulation (NS, 8 Hz, 2 msec, 30 sec) and to exogenous norepinephrine (NE, 0.2 nmol) were compared between spontaneously hypertensive rats (SHR) and the control Wistar Kyoto rats (WKY). In both WKY and SHR, ACh (3-30 nM), histamine (0.3-3 microM) and dopamine (0.3 microM) attenuated the NS-induced vasoconstrictor response as much as the NE-induced response, indicative of predominance of postsynaptic inhibition. 5HT (10-100 nM) potentiated the vasoconstrictor responses to NS significantly less than that to NE in WKY, suggestive of presynaptic inhibition. Such difference was absent in SHR. These results suggest that the presynaptic inhibition of vascular adrenergic neurotransmission by 5HT is diminished in SHR, and this may contribute to the elevated blood pressure.