Neural correlates of multisensory cue integration in macaque MSTd.
Neural correlates of multisensory cue integration in macaque MSTd.
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DOI：
10.1038/nn.2191
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发表时间：
2008-10
影响因子：
25
通讯作者：
DeAngelis, Gregory C.
中科院分区：
文献类型：
--
作者：
Gu, Yong;Angelaki, Dora E.;DeAngelis, Gregory C.
人类观察者联合收割机协同地结合多种感觉线索以获得更高的感知灵敏度，但对潜在的神经机制知之甚少。我们记录在背内侧上级颞区（MSTd）的神经元在一项任务中，训练的猴子联合收割机结合视觉和前庭线索接近最佳区分标题。在双峰刺激期间，MSTd神经元联合收割机将视觉和前庭输入与子加性权重线性组合。一致的标题偏好的视觉和前庭刺激的神经元表现出平行的行为效应的敏感性的改善。相反，具有相反偏好的神经元在线索组合下表现出降低的敏感性。一致性细胞的反应与猴子的感知决定比相反的细胞更密切相关，这表明动物在线索整合过程中更大程度地监控一致性细胞的活动。这些发现证明了非人类灵长类动物的感知线索整合，并确定了可能形成其神经基础的神经元群体。
Human observers combine multiple sensory cues synergistically to achieve greater perceptual sensitivity, but little is known about the underlying neuronal mechanisms. We recorded from neurons in the dorsal medial superior temporal area (MSTd) during a task in which trained monkeys combine visual and vestibular cues near optimally to discriminate heading. During bimodal stimulation, MSTd neurons combine visual and vestibular inputs linearly with sub-additive weights. Neurons with congruent heading preferences for visual and vestibular stimuli show improvements in sensitivity that parallel behavioral effects. In contrast, neurons with opposite preferences show diminished sensitivity under cue combination. Responses of congruent cells are more strongly correlated with monkeys' perceptual decisions than opposite cells, suggesting that the animal monitors the activity of congruent cells to a greater extent during cue integration. These findings demonstrate perceptual cue integration in non-human primates and identify a population of neurons that may form its neural basis.
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影响因子：
5.3
作者：
Gu, Y;Watkins, PV;DeAngelis, GC
通讯作者：
DeAngelis, GC
影响因子：
2.5
作者：
KOMATSU, H;WURTZ, RH
通讯作者：
WURTZ, RH
影响因子：
3.7
作者：
Molholm, S;Ritter, W;Foxe, JJ
通讯作者：
Foxe, JJ
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
影响因子：
1.9
作者：
Britten, KH;Newsome, WT;Movshon, JA
通讯作者：
Movshon, JA