Childhood Cardiometabolic Outcomes of Maternal Obesity During Pregnancy The Generation R Study
Childhood Cardiometabolic Outcomes of Maternal Obesity During Pregnancy The Generation R Study
复制标题
DOI：
10.1161/hypertensionaha.113.02671
复制
发表时间：
2014-04-01
期刊：
影响因子：
8.3
通讯作者：
Jaddoe, Vincent W. V.
中科院分区：
文献类型：
--
作者：
Gaillard, Romy;Steegers, Eric A. P.;Jaddoe, Vincent W. V.
母亲孕前肥胖与子代心脏代谢健康受损有关。目前尚不清楚这些关联是否反映了直接的宫内因果机制。在一项基于人群的前瞻性队列研究中，我们对4871名母亲、父亲和他们的孩子进行了研究，调查了母亲和父亲孕前体重指数(BMI)与儿童体脂分布和心脏代谢结果的关系，并探索了是否有任何关联可由怀孕、出生和儿童因素解释。我们在6岁时测量了儿童BMI、全身和腹部脂肪分布、血压以及血脂、胰岛素和C-肽水平。我们观察到，母亲和父亲孕前BMI越高，儿童BMI越高，全身和腹部脂肪质量指数越高，收缩压、胰岛素水平和高密度脂蛋白胆固醇水平越低(P
Maternal prepregnancy obesity is associated with impaired cardiometabolic health in offspring. Whether these associations reflect direct intrauterine causal mechanisms remains unclear. In a population-based prospective cohort study among 4871 mothers, fathers, and their children, we examined the associations of both maternal and paternal prepregnancy body mass index (BMI) with childhood body fat distribution and cardiometabolic outcomes and explored whether any association was explained by pregnancy, birth, and childhood factors. We measured childhood BMI, total body and abdominal fat distribution, blood pressure, and blood levels of lipids, insulin, and C-peptide at the age of 6 years. We observed that higher maternal and paternal prepregnancy BMI were associated with higher childhood BMI, total body and abdominal fat mass measures, systolic blood pressure, and insulin levels and lower high-density lipoprotein cholesterol levels (P