Molecular characterization of the skin fungal microbiome in patients with psoriasis
Molecular characterization of the skin fungal microbiome in patients with psoriasis
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银屑病患者皮肤真菌微生物组的分子特征
DOI：
10.1111/1346-8138.12739
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Muto M
中科院分区：
文献类型：
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作者：
Takemoto A;Cho O;Morohoshi Y;Sugita T;Muto M
皮肤表面生长着各种各样的真菌和细菌。虽然其中许多微生物，包括马拉色菌、念珠菌、链球菌和葡萄球菌，与银屑病的诱发和/或恶化有关，但对银屑病患者皮肤真菌微生物组的详细分析尚未进行。对12例银屑病患者和12例健康对照的真菌rRNA基因序列进行了分析，以确定银屑病鳞片中的真菌微生物区系。共获得高质量序列317-806条，隶属142个属，其中马拉色菌属是两个群体中最丰富的序列(银屑病患者为46.9%±114.0%，健康对照组为76.0%±114.6%)。主坐标分析表明，真菌微生物群是相互独立的。尽管皮肤真菌菌群与银屑病之间的关系尚未建立，但我们的数据表明，银屑病患者的微生物群独立于健康对照组。
The skin surface is colonized by a wide variety of fungi and bacteria. While many of these organisms, includingMalassezia,Candida,StreptococcusandStaphylococcusspecies, are associated with provocation and/or exacerbation of psoriasis, a detailed analysis of the cutaneous fungal microbiome in psoriatic patients has yet to be performed. To identify the disease‐specific fungal microbiota on psoriatic scale samples, fungal rRNA gene sequences from 12 psoriatic patients and 12 healthy controls were analyzed by pyrosequencing. A total of 317 806 high‐quality sequences were obtained, representing 142 genera.Malasseziaspecies were the most abundant sequences in both populations (46.9 ± 14.0% in psoriasis vs 76.0 ± 14.6% for healthy controls). Principal coordinate analysis revealed that the fungal microbiomes were independent. Although an association between the cutaneous fungal microbiome and psoriasis has yet to be established, our data indicate that the microbiome in patients with psoriasis is independent of that in healthy controls.