Vitamin D levels in Malawian infants from birth to 24 months
Vitamin D levels in Malawian infants from birth to 24 months
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DOI：
10.1136/archdischild-2012-302377
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发表时间：
2013-03-01
影响因子：
5.2
通讯作者：
Taha, Taha E.
中科院分区：
文献类型：
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作者：
Amukele, Timothy K.;Soko, Dean;Taha, Taha E.
我们测量了未补充维生素 D 的马拉维婴儿在 0（出生）、2、12、15、18 和 24 个月大时的纵向维生素 D 水平。还在分娩时和产后 2 个月内测量了匹配的母体血浆和母乳维生素 D-2 和 D-3 水平。使用同位素稀释液相色谱串联质谱法测定维生素 D。儿童出生时维生素 D-3 水平为成人水平的 36%，2 个月时为成人水平的 60%，12 个月时与成人水平相当。此成人等效水平随后维持至 24 个月大，其中维生素 D-3 的摩尔比为 98%。母乳中的维生素 D 水平低于检测限 0.1 ng/ml。未补充维生素 D 的马拉维母亲的母乳缺乏维生素 D。
We measured longitudinal levels of vitamin D in unsupplemented Malawian infants at 0 (birth), 2, 12, 15, 18 and 24 months of age. Matched maternal plasma and breast milk vitamin D-2 and D-3 levels were also measured at delivery and 2 months postpartum. Vitamin D was measured using isotope-dilution liquid chromatography tandem-mass spectrometry. Vitamin D-3 levels in children were 36% of adult levels at birth, 60% of adult levels at age 2 months, and at par with adult levels by 12 months of age. This adult-equivalent level is subsequently maintained through age 24 months and consisted of a 98% molar ratio of vitamin D-3. Vitamin D levels in breast milk were below the limit of detection, 0.1 ng/ml. Breast milk of unsupplemented Malawian mothers is a poor source of vitamin D.