Structural analyses of choroid after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy
Structural analyses of choroid after half-dose verteporfin photodynamic therapy for central serous chorioretinopathy
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DOI：
10.1136/bjophthalmol-2016-308921
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发表时间：
2017-04-01
影响因子：
4.1
通讯作者：
Iida, Tomohiro
中科院分区：
文献类型：
--
作者：
Izumi, Takahiko;Koizumi, Hideki;Iida, Tomohiro
目的探讨半剂量维替泊芬（vertiporfin）光动力疗法（photodynamic therapy，PDT）治疗中心性浆液性脉络膜视网膜病变（central serous chorioretinopathy，CSC）后脉络膜内结构的变化。方法回顾性分析22例CSC患者22眼的扫描源光学相干断层扫描（swep-source optical coherence tomography，OCT）图像，采用手动勾画技术和二值化方法。平均中心凹下脉络膜厚度从基线时的412.9 ± 112.9 μ m下降到3个月时的340.0 ± 111.0 μ m（p< 0.0001）。脉络膜大血管层的平均厚度从基线时的368.7 +/- 112.7 μ m降至3个月时的292.2 +/- 118.0 μ m（p< 0.0001），但平均脉络膜毛细血管中层厚度没有从基线的44.2 +/- 29.2 μ m变化到47.8 +/- 29.2 μ m，3个月时为25.7 μ m（p= 0.85）。对二值化脉络膜图像的分析显示，3 mm的中心凹下脉络膜面积从基线时的1.141 +/- 0.290 mm（2）减少到PDT后3个月时的0.962 +/- 0.320 mm（2）（p= 0.0001）。平均管腔面积从基线时的0.826 +/- 0.246 mm（2）降至3个月时的0.665 +/- 0.234 mm（2）（p= 0.0001），然而，平均基质面积从基线的0.315 ± 0.066 mm（2）到3个月的0.297 ± 0.095 mm（2）没有变化结论半剂量光动力疗法可降低CSC患者中心凹下脉络膜厚度，改变脉络膜内结构。
Background/aims To investigate the changes in the intrachoroidal structures after half-dose verteporfin photodynamic therapy (PDT) for central serous chorioretinopathy (CSC).Methods Swept-source optical coherence tomography cross-sectional images of 22 eyes of 22 patients with CSC were retrospectively analysed by a manual delineation technique and binarisation method.Results In the 22 eyes, the mean subfoveal choroidal thickness decreased from 412.9 +/- 112.9 mu m at baseline to 340.0 +/- 111.0 mu m at 3 months (p< 0.0001). The mean thickness of the large choroidal vessel layer decreased from 368.7 +/- 112.7 mu m at baseline to 292.2 +/- 118.0 mu m at 3 months (p< 0.0001), but the mean choriocapillarismedium choroidal vessel layer thickness did not change from 44.2 +/- 29.2 mu m at baseline to 47.8 +/- 25.7 mu m at 3 months (p= 0.85). Analyses of the binarised choroidal images showed that a 3 mm subfoveal choroidal area decreased from 1.141 +/- 0.290 mm(2) at baseline to 0.962 +/- 0.320 mm(2) at 3 months after PDT (p= 0.0001). The mean luminal areas decreased from 0.826 +/- 0.246 mm(2) at baseline to 0.665 +/- 0.234 mm(2) at 3 months (p= 0.0001), however, the mean stromal areas did not change from 0.315 +/- 0.066 mm(2) at baseline to 0.297 +/- 0.095 mm(2) at 3 months (p= 0.60).Conclusions Half-dose PDT reduces subfoveal choroidal thickness and alters the intrachoroidal structures in eyes with CSC.