Non-ionic macroporous polystyrene adsorbents for removal of serum toxins in liver failure by hemoperfusion
Non-ionic macroporous polystyrene adsorbents for removal of serum toxins in liver failure by hemoperfusion
复制标题
非离子大孔聚苯乙烯吸附剂去除血液灌流肝衰竭血清毒素
DOI：
10.3109/21691401.2016.1138494
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发表时间：
2017-02-01
影响因子：
5.8
通讯作者：
Yu, Yaoting
中科院分区：
文献类型：
--
作者：
Chen, Jian;Han, Wenyan;Yu, Yaoting
强碱性阴离子交换树脂（例如，BL-300）目前用于临床血液灌流中消除血液中的胆红素。然而，树脂在去除肝素和激活凝血方面存在潜在弱点。为了克服这一缺点，我们采用悬浮聚合法制备了一种具有丰富介孔和高比表面积的新型非离子型大孔聚苯乙烯吸附剂（SZ-9）。实验结果表明SZ-9对胆红素的吸附能力优于BL-300。此外，在全血血液灌流期间观察到更好的血液相容性。因此，SZ-9吸附剂可能是一种有效的替代阴离子交换树脂去除胆红素的血液灌流。
Strong base anion exchange resin (e.g., BL-300) is currently used to eliminate bilirubin from blood in clinical hemoperfusion. However, there is a potential weakness of the resin to remove heparin and activation of coagulation. To overcome this weakness, we prepared a novel non-ionic macroporous polystyrene adsorbent (SZ-9) with rich mesopores and high surface area by suspension polymerization. Test results indicated that SZ-9 performed better adsorption capacity for bilirubin than BL-300. In addition, better blood compatibility was observed during whole blood hemoperfusion. Therefore, adsorbent SZ-9 might be an efficient alternative to anion exchange resin for the removal of bilirubin in hemoperfusion.