Social isolation reduces serotonergic fiber density in the inferior colliculus of female, but not male, mice
Social isolation reduces serotonergic fiber density in the inferior colliculus of female, but not male, mice
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DOI：
10.1016/j.brainres.2018.05.010
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发表时间：
2018-09-01
期刊：
影响因子：
2.9
通讯作者：
Hurley, Laura M.
中科院分区：
文献类型：
--
作者：
Keesom, Sarah M.;Morningstar, Mitchell D.;Hurley, Laura M.
早期的生活经历，包括母亲的剥夺和青少年时期的社会孤立，对一系列成年人的社会行为有着深远的影响。断奶后啮齿动物的社会隔离部分通过改变神经调节系统（包括多巴胺能系统）影响行为。对于社会行为来说，多巴胺能系统丰富地支配涉及声音交流的大脑区域，包括听觉系统。然而，隔离对听觉系统的多巴胺能输入的影响仍有待研究。在这里，我们评估是否4周断奶后的个人住房改变了下丘（IC），听觉中脑核，其中5-羟色胺改变神经元诱发的活动中的多巴胺能纤维密度。将单独圈养的雄性和雌性小鼠与三只一组的群居同种小鼠进行比较。随后用5-羟色胺转运蛋白的抗体观察5-羟色胺能投射，该抗体以相对高的选择性标记5-羟色胺能纤维。纤维密度估计在三个主要的子区域的IC使用线扫描强度分析。单独圈养的雌性小鼠显示出相对于社会圈养的雌性显著降低的纤维密度，这伴随着单独圈养的雌性体重较低。与此相反，社会隔离并不影响男性IC中的多巴胺能纤维密度。这一发现表明，多巴胺能神经系统对社会隔离的敏感性是性别依赖的，这可能是由于隔离对心理社会压力的影响存在性别差异。由于血清素的可用性取决于社会背景，这一发现进一步表明，社会隔离可以改变听觉处理的急性社会调节。(C)2018爱思唯尔B. V.保留所有权利。
Early-life experiences, including maternal deprivation and social isolation during adolescence, have a profound influence on a range of adult social behaviors. Post-weaning social isolation in rodents influences behavior in part through the alteration of neuromodulatory systems, including the serotonergic system. Of significance to social behavior, the serotonergic system richly innervates brain areas involved in vocal communication, including the auditory system. However, the influence of isolation on serotonergic input to the auditory system remains underexplored. Here, we assess whether 4 weeks of post weaning individual housing alters serotonergic fiber density in the inferior colliculus (IC), an auditory midbrain nucleus in which serotonin alters auditory-evoked activity. Individually housed male and female mice were compared to conspecifics housed socially in groups of three. Serotonergic projections were subsequently visualized with an antibody to the serotonin transporter, which labels serotonergic fibers with relatively high selectivity. Fiber densities were estimated in the three major subregions of the IC using line-scan intensity analysis. Individually housed female mice showed a significantly reduced fiber density relative to socially housed females, which was accompanied by a lower body weight in individually housed females. In contrast, social isolation did not affect serotonergic fiber density in the IC of males. This finding suggests that sensitivity of the serotonergic system to social isolation is sex dependent, which could be due to a sex difference in the effect of isolation on psychosocial stress. Since serotonin availability depends on social context, this finding further suggests that social isolation can alter the acute social regulation of auditory processing. (C) 2018 Elsevier B.V. All rights reserved.