NORMAL MAMMALIAN MUSCLE DIFFERENTIATION AND GENE CONTROL OF ISOCITRATE DEHYDROGENASE SYNTHESIS
NORMAL MAMMALIAN MUSCLE DIFFERENTIATION AND GENE CONTROL OF ISOCITRATE DEHYDROGENASE SYNTHESIS
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DOI：
10.1073/pnas.58.2.592
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发表时间：
1967-01-01
影响因子：
11.1
通讯作者：
BAKER, WW
中科院分区：
文献类型：
--
作者：
MINTZ, B;BAKER, WW
图1.-同种异型小鼠中预期同工酶结果的图，”分区”（左）与骨骼肌发育的“融合”（右）模型。当不同NADP-异柠檬酸脱氢酶基因型的纯合细胞共存时，会产生异核体，导致成肌细胞融合，形成杂合酶。酶分子在细胞质中由多肽亚基形成二聚体。
FIG. 1.-Diagram of expected isozyme results in allophenic mice, on the" division"(left) vs." fusion"(right) models of skeletal muscle development. When homozygous cellsof different NADP-isocitrate dehydrogenase genotypes coexist, heterokaryons would resultin the event of myoblast fusion, and hybrid enzyme could be formed. Enzyme molecules are represented as dimers formed inl the cytoplasm from polypeptide subunits (see text).