Therapeutic potential of C1632 by inhibition of SARS-CoV-2 replication and viral-induced inflammation through upregulating let-7
Therapeutic potential of C1632 by inhibition of SARS-CoV-2 replication and viral-induced inflammation through upregulating let-7
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DOI：
10.1038/s41392-021-00497-4
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发表时间：
2021
影响因子：
39.3
通讯作者：
Huang Hui
中科院分区：
文献类型：
--
作者：
Xie Chen;Chen Yanlian;Luo Dongling;Zhuang Zhen;Jin Heping;Zhou Haoxian;Li Xiaocui;Lin Haijun;Zheng Xiaohui;Zhang Jing;Wang Peihui;Zhao Jincun;Zhao Yong;Huang Hui
The COVID-19 pandemic caused by SARS-CoV-2 has led to acute respiratory distress syndrome (ARDS) with a high rate of death. An excessive inflammatory response, caused by virus infection, is associated with severe clinical manifestations that may lead to death of patients. Therefore, the blockage of virus replication and suppression of hyper-inflammatory response are beneficial for COVID-19 treatment. However, the drug targeting both virus and hyper-inflammation, as far as we know, is not available yet.
